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| Content Provider | Journal of Biological Chemistry (JBC) |
|---|---|
| Author | Sasaki, Aya Masuda, Yoshiko Ohta, Yasutaka Ikeda, Kyoji Watanabe, Ken |
| Abstract | Members of the Smad proteins transmit signals triggered by the ligands of transforming growth factor (TGF)-β superfamily. Ligand-activated receptors induce phosphorylation of so-called receptor-regulated Smads, which then accumulate in the nucleus to participate in target gene transcription, in collaboration with Smad-interacting proteins. We performed yeast two-hybrid screening and identified filamin, a cytoskeletal actin-binding protein 280, as a Smad5-interacting protein. Filamin was found to be associated not only with Smad5 but also with other Smad proteins, including TGF-β/activin receptor-regulated Smad2. TGF-β signaling was defective in filamin-deficient human melanoma cells M2 compared with a filamin-transfected subline A7, as determined by TGF-β-responsive reporter gene activation and Smad2 nuclear accumulation. M2 cells restored TGF-β responsiveness following transient transfection of full-length filamin encoding vector. The defective TGF-β signaling in M2 cells seemed to be due to impaired receptor-induced serine phosphorylation of Smad2. These results suggest that filamin plays an important role in Smad-mediated signaling. |
| Related Links | http://www.jbc.org/content/276/21/17871.abstract |
| Ending Page | 17877 |
| Starting Page | 17871 |
| Page Count | 7 |
| File Format | HTM / HTML PDF |
| ISSN | 00219258 |
| Journal | Journal of Biological Chemistry (JBC) |
| Issue Number | 21 |
| Volume Number | 276 |
| DOI | 10.1074/jbc.M008422200 |
| e-ISSN | 1083351X |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology |
| Publisher Date | 2001-05-25 |
| Access Restriction | Open |
| Subject Keyword | Transforming growth factor (TGF) Mitogen-activated protein kinase (MAPK) Minimal essential medium (MEM) Fetal bovine serum (FBS) Periventricular heterotopia (PH) Hemagglutinin (HA) Polyacrylamide gel electrophoresis (PAGE) Glutathione S-transferase (GST) Bone morphogenetic protein (BMP) Actin binding protein (ABP) MECHANISMS OF SIGNAL TRANSDUCTION |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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