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| Content Provider | Journal of Biological Chemistry (JBC) |
|---|---|
| Author | Orivel, Jérôme Redeker, Virginie Caer, Jean-Pierre Le Krier, François Revol-Junelles, Anne-Marie Longeon, Arlette Chaffotte, Alain Dejean, Alain Rossier, Jean |
| Abstract | The antimicrobial, insecticidal, and hemolytic properties of peptides isolated from the venom of the predatory ant Pachycondyla goeldii, a member of the subfamily Ponerinae, were investigated. Fifteen novel peptides, named ponericins, exhibiting antibacterial and insecticidal properties were purified, and their amino acid sequences were characterized. According to their primary structure similarities, they can be classified into three families: ponericin G, W, and L. Ponericins share high sequence similarities with known peptides: ponericins G with cecropin-like peptides, ponericins W with gaegurins and melittin, and ponericins L with dermaseptins. Ten peptides were synthesized for further analysis. Their antimicrobial activities against Gram-positive and Gram-negative bacteria strains were analyzed together with their insecticidal activities against cricket larvae and their hemolytic activities. Interestingly, within each of the three families, several peptides present differences in their biological activities. The comparison of the structural features of ponericins with those of well-studied peptides suggests that the ponericins may adopt an amphipathic α-helical structure in polar environments, such as cell membranes. In the venom, the estimated peptide concentrations appear to be compatible with an antibacterial activity in vivo. This suggests that in the ant colony, the peptides exhibit a defensive role against microbial pathogens arising from prey introduction and/or ingestion. |
| Related Links | http://www.jbc.org/content/276/21/17823.abstract |
| Ending Page | 17829 |
| Starting Page | 17823 |
| Page Count | 7 |
| File Format | HTM / HTML PDF |
| ISSN | 00219258 |
| Journal | Journal of Biological Chemistry (JBC) |
| Issue Number | 21 |
| Volume Number | 276 |
| DOI | 10.1074/jbc.M100216200 |
| e-ISSN | 1083351X |
| Language | English |
| Publisher | American Society for Biochemistry and Molecular Biology |
| Publisher Date | 2001-05-25 |
| Access Restriction | Open |
| Subject Keyword | High pressure liquid chromatography (HPLC) Minimal inhibitory concentration (MIC) Trifluoroethanol (TFE) PROTEIN STRUCTURE AND FOLDING |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Molecular Biology |
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