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Electro-oxidation and simultaneous determination of amlodipine and atorvastatin in commercial tablets using carbon nanotube modified electrode

Content Provider	IET Digital Library
Author	Mohammadi, Ali Moghaddam, Abdolmajid Bayandori Eilkhanizadeh, Kordestan Alikhani, Elham Mozaffari, Shahla Yavari, Tahereh
Abstract	Amlodipine besylate and atorvastatin calcium have been determined by the simultaneous voltammetric method at a multi-walled carbon nanotubes:graphite (MWCNTs:G) paste electrode. In comparison with a glassy carbon electrode, the prepared electrode showed an increase in the peak current because of the high electroactive surface area and excellent electronic conductivity of MWCNTs. The dependence of currents and potentials on pH were investigated for these components at the surface of the MWCNTs:G paste electrode. Differential pulse voltammetry was applied as a sensitive technique for simultaneous determination of the drugs in commercial tablets. By anodic differential pulse voltammetry, the calibration plot was linear in the range of 2.5–100 µg/ml with standard deviation between 2.7–7.1 and 1.8–8.3% for amlodipine and atorvastatin, respectively. The detection limit was 1 µg/ml at the prepared electrode in the buffered solution pH 6.
Starting Page	413
Ending Page	417
Page Count	5
Volume Number	8
e-ISSN	17500443
Issue Number	Issue 8, Aug (2013)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/mnl/8/8
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/mnl.2013.0080
Journal	Micro & Nano Letters
Access Restriction	Open
Rights Holder	© The Institution of Engineering and Technology
Subject Keyword	Amlodipine Besylate Amlodipine Simultaneous Determination Anodic Differential Pulse Voltammetry Atorvastatin Calcium Atorvastatin Simultaneous Determination Bioelectric Potentials Bioelectricity Buffered Solution Buffered Solution PH C-C Calcium Compounds Calibration Calibration Plot Carbon Nanotube Modified Electrode Carbon Nanotubes Chemical Analysis Chemical Sensor Chemical Variables Measurement Commercial Tablets Drugs Electrical Conductivity Electro oxidation Electroactive Surface Area Electrochemical Analytical Method Electrochemical Electrodes Electrochemical Sensor Electrochemistry And Electrophoresis Electronic Conductivity Glassy Carbon Electrode Graphite Measurement Standard And Calibration Microsensors And Nanosensors Multiwalled Carbon Nanotube-graphite Paste Electrode Nanosensor Oxidation Patient Care And Treatment Peak Current PH Potential Reaction Mechanisms Sensitivity Analysis Simultaneous Voltametric Method Specific Chemical Reactions Standard Deviation Voltammetry
Content Type	Text
Resource Type	Article

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