Simultaneous spectrophotometric determination of amlodipine besylate and atorvastatin calcium in binary mixture

Content Provider	Semantic Scholar
Author	Sahu, Rajnikanta Patel, Vandana B.
Copyright Year	2007
Abstract	A rapid, simple, accurate and precise UV Spectrophotometric method using simultaneous equation was developed for the simultaneous determination of amlodipine besylate and atorvastatin calcium in a binary mixture. In the proposed method, the signals were measured at 238.2 and 246.6 nm corresponding to the absorbance maxima of amlodipine besylate and atorvastatin calcium in methanol, respectively. Linearity was observed in the concentration range of 5-30 µg/ml for both the drugs. Concentration of each drug was obtained by using the absorptivity values calculated for both the drugs at two wavelengths, 238.2 and 246.6 nm and solving the simultaneous equations. The method was validated statistically and recovery study was performed to confirm the accuracy of the method. Laboratory prepared synthetic mixture was successfully analyzed using the developed method.
Starting Page	110
Ending Page	111
Page Count	2
File Format	PDF HTM / HTML
DOI	10.4103/0250-474X.32119
Volume Number	69
Alternate Webpage(s)	http://www.ijpsonline.com/articles/simultaneous-spectrophotometric-determination-of-amlodipine-besylate-and-atorvastatin-calcium-in-binary-mixture.pdf
Alternate Webpage(s)	https://doi.org/10.4103/0250-474X.32119
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article