NDLI: Application of β-CD/HA composite as a potential SD carrier to improve the dissolution of curcumin

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Volume 14 (2019) : Issue 3, Mar

Volume 14 (2019) : Issue 2, Feb

Volume 14 (2019) : Issue 1, Jan

The Journal of Engineering

Application of β-CD/HA composite as a potential SD carrier to improve the dissolution of curcumin

Content Provider	IET Digital Library
Author	Xu, Defeng Wang, Wenjie Yang, Mengmeng Bhaduri, Sarit B. Huang, Chingcheng Yang, Lei Zhang, Zhenyi Zhou, Huan
Abstract	Curcumin is a natural active constituent with a great variety of beneficial biological and pharmacological activities, is a practically water-insoluble component. The scope of the present work was to prepare a solid dispersion (SD) formulation to enhance the dissolution rate of curcumin. The SD was prepared using curcumin and β-cyclodextrin (CD)/HA via a classical ethanol-based solvent evaporation method. The as-prepared β-CD/HA and SDs were selectively characterised by various analytical techniques including X-ray diffraction, transmission electron microscopy, scanning electron microscopy, specific surface area/pore size analysis, Fourier transform infrared spectroscopy, and high-performance liquid chromatography. According to the dissolution tests, it was confirmed that β-CD/HA–curcumin SD can significantly enhance the dissolution of curcumin. In addition, an increasing trend was seen between the β-CD weight ratio and the dissolution rate of curcumin, and β-CD/HA–curcumin (9:1) SD was shown to be the best formulation among all tested samples with over 90% curcumin dissolved in 180 min. Besides, β-CD/HA–curcumin (9:1) SD exhibited pH and medium-dependent curcumin release behaviours. The antioxidant activity of released curcumin showed no difference to original curcumin. These results clearly demonstrated β-CD/HA can be a promising SD carrier to improve the dissolution of curcumin.
Starting Page	353
Ending Page	358
Page Count	6
Volume Number	14
e-ISSN	17500443
Issue Number	Issue 4, Apr (2019)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/mnl/14/4
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/mnl.2018.5096
Journal	Micro & Nano Letters
Publisher Date	2019-04-03
Access Restriction	Open
Rights Holder	© The Institution of Engineering and Technology
Subject Keyword	Antioxidant Activity Biomedical Material CD-HA Composite Chromatography Composite Material Curcumin Dissolution Curcumin Release Cyclodextrin Dissolution Rate Dissolving Drug Delivery System Drugs Fourier Transform Infrared Spectra Fourier Transform Infrared Spectroscopy High-performance Liquid Chromatography Material Preparation Method of Preparation of Material Mixing Particle Size Patient Care And Treatment Pore Size Analysis Potential SD Carrier Released Curcumin Scanning Electron Microscopy Segregation Solid Dispersion Formulation Solubility Specific Surface Area Transmission Electron Microscopy X-Ray Diffraction Β-CD-HA–curcumin
Content Type	Text
Resource Type	Article

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