NDLI: Development of surface engineered mesoporous alumina nanoparticles: drug release aspects and cytotoxicity assessment

Content Provider	IET Digital Library
Author	More, Mahesh P. Ganguly, Payal R. Pandey, Abhijeet P. Dandekar, Prajakta P. Jain, Ratnesh D. Patil, Pravin O. Deshmukh, Prashant K.
Abstract	The present investigation deals with successful synthesis and surface functionalisation of mesoporous alumina (MeAl) nanoparticles by simplified sol–gel method using cetyl trimethyl ammonium bromide (CTAB) and pluronic as a template. Surface functionalisation of MeAl was performed to determine the selectivity of surface groups for coupling with model drug molecule. Repaglinide a BCS class II drug was loaded as a model drug on synthesised MeAl nanoparticle and studied for its sustained release capability. The synthesised and repaglinide loaded MeAl nanoparticles were characterised by Fourier transform infrared Spectroscopy, X-ray diffraction, field emission scanning electron microscopy with EDAX, Transmission electron microscopy and differential scanning calorimetric. Results from the dissolution study confirmed the sustained release behaviour of the nanparticles which was up to 24 h. The cell viability assay demonstrated that 0.2 to 1 mg/ml concentration of MeAl was significantly less cytotoxic to the Chinese Hamster Ovary (CHO) cells. The authors’ experimental studies suggest that MeAl can be used as drug carrier and have a potential to increase the stability, loading efficiency and patient compliance for poorly water-soluble drugs such as repaglinide.
Starting Page	661
Ending Page	668
Page Count	8
ISSN	17518741
Volume Number	11
e-ISSN	1751875X
Issue Number	Issue 6, Sep (2017)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/iet-nbt/11/6
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/iet-nbt.2016.0225
Journal	IET Nanobiotechnology
Publisher Date	2017-02-17
Access Restriction	Open
Rights Holder	© The Institution of Engineering and Technology
Subject Keyword	Al2O3 Alumina BCS Class II Drug Cell Viability Assay Cellular Biophysics Cetyl Trimethyl Ammonium Bromide Chinese Hamster Ovary Cell CTAB Cytotoxicity Assessment Deposition from Liquid Phase (melts And Solutions) Differential Scanning Calorimetry Drug Carrier Drug Delivery System Drug Release Aspects EDAX Field Emission Electron Microscopy Field Emission Scanning Electron Microscopy Fourier Transform Infrared Spectra Fourier Transform Infrared Spectroscopy MeAl Mesoporous Material Model Drug Molecule Nanomedicine Nanoparticle Nanotechnology Application in Biomedicine Patient Care And Treatment Pluronic Poorly Water-soluble Drugs Repaglinide Sol Gel Processing Sol–gel Method Surface Acoustic Wave Surface Engineered Mesoporous Alumina NanoParticle Surface Functionalisation Toxicology Transmission Electron Microscopy X-Ray Chemical Analysis X-Ray Diffraction
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering Biotechnology

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