NDLI: Factors affecting the antibacterial activity of chitosan-silver nanocomposite

Content Provider	IET Digital Library
Author	Sherif, Hadeer H. A. Khalil, Safaa K. H. Hegazi, Ahmed G. Khalil, Wafaa A. Moharram, Mohamed A.
Abstract	This study provides the optimum preparation parameters of chitosan-silver nanoparticles composite (CSNC) with promising antibacterial activity against the most common bacterial infections found on burn wounds. CSNC was synthesised by simple green chemical reduction method with different preparation factors. Chitosan was used to reduce silver nitrate and stabilise silver nanoparticles in the medium. For this reason, spectroscopic and microscopic techniques as, ultraviolet-visible Fourier transform infrared spectroscopy and transmission electron microscopy were used in the study of the molecular and morphological properties of the resultant composites. Furthermore, the composite was assessed in terms of Ag-ions release by AAS and its efficacy as antibacterial material. As a result, CSNC showed stronger antibacterial effect than its individual components (chitosan and silver nitrate solutions) towards Gram-positive (Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa and Escherichia coli) bacteria. CSNC prepared in this study showed highest inhibition percentage of bacterial growth up to 96% at concentration of 220 μg/ml.
Starting Page	731
Ending Page	737
Page Count	7
ISSN	17518741
Volume Number	11
e-ISSN	1751875X
Issue Number	Issue 6, Sep (2017)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/iet-nbt/11/6
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/iet-nbt.2016.0249
Journal	IET Nanobiotechnology
Publisher Date	2017-04-28
Access Restriction	Open
Rights Holder	© The Institution of Engineering and Technology
Subject Keyword	Antibacterial Activity Bacterial Growth Bacterial Infections Biomedical Material Burn Wounds Chitosan-silver Nanocomposite Chitosan-silver Nanoparticles Composite Condensed Matter CSNC Escherichia Coli Filled Polymers Fourier Transform Spectra Gram-negative Bacteria Gram-positive Bacteria Green Chemical Reduction Method Infrared And Raman Spectra And Scattering (Condensed Matter) Infrared Spectra Method of Nanofabrication And Processing Microorganisms Molecular Property Morphological Property Nanocomposite Nanofabrication Nanomedicine Nanoparticle Nanotechnology Application in Biomedicine Optimum Preparation Parameter Pseudomonas Aeruginosa Reaction Mechanisms Reduction (Chemical) Silver Compound Specific Chemical Reactions Staphylococcus Aureus Transmission Electron Microscopy Ultraviolet Spectra Ultraviolet-visible Fourier Transform Infrared Spectroscopy Visible And Ultraviolet Spectra Visible Spectra Wounds
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering Biotechnology

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