NDLI: In-vitro and in-vivo evaluation of chitosan-based thermosensitive gel containing lorazepam NLCs for the treatment of status epilepticus

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Volume 14 (2020) : Issue 1, Feb

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In-vitro and in-vivo evaluation of chitosan-based thermosensitive gel containing lorazepam NLCs for the treatment of status epilepticus

Content Provider	IET Digital Library
Author	Taymouri, Somayeh Minaiyan, Mohsen Ebrahimi, Farnaz Tavakoli, Naser
Abstract	The objective of this study was to develop an in-situ gel containing lorazepam (LZM) loaded nanostructured lipid carriers (NLCs) for direct nose-to-brain delivery in order to increase drug therapeutic efficacy in the treatment of epilepsy. Accordingly, LZM loaded NLCs were formulated using emulsification solvent diffusion and evaporation method; then the effects of the formulation variables on different physicochemical characteristics of NLCs were investigated. Thermosensitive in-situ gels containing LZM-NLCs were prepared using a combination of chitosan and β-glycerol phosphate (β-GP). The anticonvulsant efficacy of LZM-NLCs-Gel was then examined using the pentylenetetrazole (PTZ) model. The optimised NLCs were spherical, showing the particle size of 71.70 ± 5.16 nm and the zeta potential of −20.06 ± 2.70 mV. The pH and gelation time for the chitosan solution with 15% (w/v) β-GP were determined to be 7.12 ± 0.03 and 5.33 ± 0.58 min, respectively. The in-vivo findings showed that compared with the control group and the group that received LZM-Gel, the occurrence of PTZ-induced seizures in the rats was significantly reduced by LZM-NLCs-Gel after intranasal administration. These results, therefore, suggested that the LZM-NLCs-Gel system could have potential applications for brain targeting through nasal route and might increase LZM therapeutic efficacy in the treatment of epilepsy.
Starting Page	148
Ending Page	154
Page Count	7
ISSN	17518741
Volume Number	14
e-ISSN	1751875X
Issue Number	Issue 2, Apr (2020)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/iet-nbt/14/2
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/iet-nbt.2019.0156
Journal	IET Nanobiotechnology
Publisher Date	2019-12-04
Access Restriction	Open
Rights Holder	© The Institution of Engineering and Technology
Subject Keyword	Anticonvulsant Efficacy Biomedical Material Brain Cellular Biophysics Chitosan Solution Chitosan-based Thermosensitive Gel Drug Delivery System Drug Therapeutic Efficacy Drugs Electrochemistry And Electrophoresis Electrokinetic Effects Emulsification Solvent Diffusion Epilepsy Treatment Evaporation Method Gelation Time Gels And Sols In-vitro Evaluation In-vivo Evaluation Intranasal Administration Lorazepam Loaded Nanostructured Lipid Carriers Lorazepam NLCs LZM Therapeutic Efficacy LZM-NLC-gel System Medical Disorders Nanofabrication Nanomedicine Nanoparticle Nanotechnology Application in Biomedicine Nanotube And Nanostructured Material Nose-to-brain Delivery Optimised NLCs Particle Size Patient Care And Treatment Pentylenetetrazole Model PH Physicochemical Characteristic Polymer Gels PTZ-induced Seizures Received LZM-Gel Status Epilepticus Treatment Structure of Solid Clusters Thermosensitive In-situ Gel Zeta Potential Β-glycerol Phosphate Β-GP
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering Biotechnology

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