NDLI: High-performance immunosensor for urine albumin using hybrid architectures of ZnO nanowire/carbon nanotube

Content Provider	IET Digital Library
Author	Tabatabaei, Mohamad Kazem Fard, Hassan Ghafori Koohsorkhi, Javad Arough, Javad Mohammadnejad
Abstract	In this work, the authors reported the hybrid architecture of carbon nanotube (CNT)–zinc oxide (ZnO) nanowire as a multi-functional probe in amperometric immunosensor for the detection of urine albumin. Low-cost substrate such as glass is possible because of novel low-temperature growth process of CNT/ZnO nanowires as a multi-function electrode in this sensor. Based on Schottky like behaviour this structure exhibit excellent high current density to achieve higher performance. Measurement of urine albumin is a new way for early detection of diabetic and also low concentration of it in culture media is also considered in order to verify the conversion of stem cells to liver cells. Human albumin serum antibody is used as a selective and sensitive part. The amperometric performance of immunosensor is studied and showed excellent performance for detection of albumin in urine samples. Very high linear range (from 3.3 ng/µl to 3.3 mg/µl) with a correlation coefficient of 0.825 and low detection limit (3.3 ng/µl or 4.96 × 10−8 mol l−1) are the main characteristics of this sensor. Due to the high dynamic range and sensitivity, this sensor was also used in medical diagnosis and biomedical applications.
Starting Page	126
Ending Page	132
Page Count	7
ISSN	17518741
Volume Number	14
e-ISSN	1751875X
Issue Number	Issue 2, Apr (2020)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/iet-nbt/14/2
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/iet-nbt.2018.5165
Journal	IET Nanobiotechnology
Publisher Date	2019-10-04
Access Restriction	Open
Rights Holder	© The Institution of Engineering and Technology
Subject Keyword	Amperometric Immunosensor Amperometric Sensor Biomedical Application Biosensor Carbon Nanotubes Chemical Sensor Chemical Variables Measurement CNT Current Density Diabetic Detection Electrochemical Electrodes Electrochemistry And Electrophoresis Fullerene Human Albumin Serum Antibody Detection II-VI SemiConductor Liver Cell Conversion Low-temperature Growth Process Medical Diagnosis MEMS And NEMS Device Technology Micromechanical And Nanomechanical Device And System Microsensors And Nanosensors Multifunction Electrode Probe Nanosensor Nanotube And Related Device Nanowire-carbon Nanotube Architectures Nanowires Schottky Effect Schottky Like Behaviou Sensing And Detecting Device Stem Cell Conversion Urine Albumin Measurement Wide Band Gap SemiConductor Zinc Compound ZnO-C
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering Biotechnology

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