Please wait, while we are loading the content...
Please wait, while we are loading the content...
| Content Provider | IET Digital Library |
|---|---|
| Author | Xiao, Gong Zou, Junlin Xiao, Xiangcheng |
| Abstract | Lycopene (LYC) is known to protect cells from oxidative damage caused by free radicals in human tissues. In the present study, the authors designed a LYC-loaded sialic acid (SA)-conjugated poly(D,L-lactide-co-glycolide) (PLGA) nanoparticle (LYC-NP) to enhance the therapeutic efficacy of LYC in acute kidney injury. The characteristics of the LYC-NPs were defined according to particle size, morphology, and in vitro drug release. The LYC-NPs exhibited a controlled release of LYC over 48 h. Confocal laser scanning microscopy clearly highlighted the targeting potential of SA. Enhanced green fluorescence was observed for the LYC-NPs in H2O2-treated human umbilical vein endothelial cells, indicating enhanced internalisation of NPs. The LYC-NPs showed significantly greater cell viability than H2O2-treated cells. In addition, the LYC-NPs remarkably reduced proinflammatory cytokine levels, attributable mainly to the increased cellular internalisation of the SA-based carrier delivery system. Furthermore, protein levels of caspase-3 and -9 were significantly down-regulated after treatment with the LYC-NPs. Overall, they have demonstrated that SA-conjugated PLGA-NPs containing LYC could be used to treat kidney injury. |
| Starting Page | 341 |
| Ending Page | 345 |
| Page Count | 5 |
| ISSN | 17518741 |
| Volume Number | 14 |
| e-ISSN | 1751875X |
| Issue Number | Issue 4, Jun (2020) |
| Alternate Webpage(s) | https://digital-library.theiet.org/content/journals/iet-nbt/14/4 |
| Alternate Webpage(s) | https://digital-library.theiet.org/content/journals/10.1049/iet-nbt.2019.0363 |
| Journal | IET Nanobiotechnology |
| Publisher Date | 2020-03-25 |
| Access Restriction | Open |
| Rights Holder | © The Institution of Engineering and Technology |
| Subject Keyword | Biochemistry Biological Tissues Biomedical Material Blood Vessels Cancer Cell Viability Cellular Biophysics Cellular Internalisation Chemotherapeutic Drug-induced Kidney Injury Confocal Laser Scanning Microscopy Drug Delivery System Drugs Fluorescence Green Fluorescence Haemodynamics Human Tissues Human Umbilical Vein Endothelial Cell In Vitro Drug Release Injuries Kidney Low-Dimensional Structure: Growth, Structure And Nonelectronic Property LYC-loaded Sialic Acid-conjugated Poly(D,L-lactide-co-glycolide) Nanoparticle LYC-NP Lycopene Molecular Biophysics Nanofabrication Nanomedicine Nanoparticle Nanotechnology Application in Biomedicine Optical And Laser Radiation Optical Microscopy Particle Size Patient Care And Treatment Physical Chemistry of Biomolecular Solutions And Condensed State Pneumodynamics Proinflammatory Cytokine Levels Protective Effect Proteins SA-based Carrier Delivery System SA-conjugated PLGA-NP Sialic Acid-conjugated PLGA NanoParticle Time 48.0 Hour Toxicology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering Biotechnology |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|