NDLI: Glutamate, GABA and dopamine hydrochloride concentration effects on the conductivity and impedance of cerebrospinal fluid

Content Provider	IEEE Xplore Digital Library
Author	Xing, P. Miled, M.A. Sawan, M.
Copyright Year	2013
Description	Author affiliation: Dept. of Electr. Eng., Ecole Polytech. de Montreal, Montréal, QC, Canada (Xing, P.; Miled, M.A.; Sawan, M.)
Abstract	This paper shows the effect of neurotransmitter concentrations on the local conductivity and impedance of the cerebrospinal fluid in addition to their biological effects. Three neurotransmitters are studied: glutamate and gamma-Aminobutyric acid (GABA), which are the major excitatory and inhibitory neurotransmitters respectively, and dopamine, which is involved in many psychiatric disorders such as Parkinson's disease, drug's addiction and schizophrenia. We used different concentrations of artificial cerebrospinal fluid (ACSF) since its conductivity is too high. Obtained results prove that neurotransmitter concentration can be detected by sensing the conductivity and the impedance of the ACSF. Indeed, when the glutamate concentration increases from 6 mM to 58 mM the conductivity of 0.5% ACSF jumps from 0.03 S/m to 0.07 S/m while its impedance decreases from 2.8 kΩ to 1.5 kΩ. However, GABA concentration does not affect the conductivity of the ACSF but we observed a significant decrease of impedance of the 0.5% ACSF solution from 6.5 kΩ to 4 kΩ when GABA concentration increases from 5 mM to 500 mM. In the case of dopamine hydrochloride, an important change of conductivity and impedance is observed with 10% ACSF solution which varies from 0.3 S/m to 1.2 S/m and from 460 Ω to 200 kΩ respectively when the dopamine concentration drops from 5 mM to 100 mM.
Starting Page	1037
Ending Page	1040
File Size	1550634
Page Count	4
File Format	PDF
ISBN	9781467319690
ISSN	19483554
DOI	10.1109/NER.2013.6696114
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-11-06
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Electrodes Neurotransmitters Conductivity Conductivity measurement Frequency measurement Sensors Impedance
Content Type	Text
Resource Type	Article

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