NDLI: A combined neural-oxygen sensing multi-channel electrode array

Content Provider	IEEE Xplore Digital Library
Author	Khine, M. Thompson, J.K. Bierer, S.M. Altamirano, L.J. Freeman, R.D. Lee, L.P.
Copyright Year	2003
Description	Author affiliation: Berkeley Sensor & Actuator Center, California Univ., Berkeley, CA, USA (Khine, M.)
Abstract	We are developing a neural probe with integrated oxygen sensors to investigate the relationship between tissue oxygenation and neural activity within the brain. A quantitative understanding of this relationship at a submillimeter scale could enhance current non-invasive brain imaging techniques and extend their application in science and medicine. The neural probe is a microfabricated multichannel electrode array. Two of 16 recording sites of the array were converted to amperometric oxygen sensors by applying a polarization voltage relative to a reference electrode. The remaining electrode sites were used to record neural activity. In-vitro tests demonstrated a linear relationship between oxygen sensor current and dissolved oxygen. Preliminary in-vivo tests within the cat's visual cortex demonstrated stimulus induced oxygen responses similar to those obtained using a conventional single channel Clark-style oxygen sensor.
Starting Page	204
Ending Page	207
File Size	344726
Page Count	4
File Format	PDF
ISBN	0780375793
DOI	10.1109/CNE.2003.1196793
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2003-03-20
Publisher Place	Italy
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Brain Polarization Voltage Amperometric sensors Probes In vitro Biomedical electrodes Sensor arrays Testing Biomedical imaging
Content Type	Text
Resource Type	Article

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