NDLI: Relationship between expression of IL-8 mRNA in peripheral blood and women with endometriosis

Content Provider	IEEE Xplore Digital Library
Author	Sun Lin Wang Jian Gao Ke-fa Hu Chang-ling
Copyright Year	2009
Description	Author affiliation: Department of Obstetrics and Gynecology, Anhui University of Science & Technology, Huainan 232001, China (Sun Lin; Wang Jian) \|\| Department of Infectious Diseases, the Second Miner Hospital of Huainan, 232052, Anhui, China (Hu Chang-ling) \|\| Department of Aetiology and Immunology, Anhui University of Science and Technology, Huainan 232001, China (Gao Ke-fa)
Abstract	Objective: To study the relationship between expression of IL-8 mRNA in peripheral blood and women with endometriosis and its clinical significance. Methods: The women with endometriosis were treated with Danazol and the level of IL-8 mRNA in their peripheral blood was detected by Real-time PCR. Results: The level of IL-8 mRNA in peripheral blood of women with endometriosis was 1.1339−0.1428. It was high significance between in endometriosis and without endometriosis (P≪0.01). However, the level of IL-8 mRNA in endometriosis in stage of I≈II and in stage of III were 1.1023−0.1371 and 1.1866−0.1543, few significance difference in two subgroups (P≫0.05). After treatment of Danazol for six months, the expression of IL-8 mRNA in peripheral blood was 1.0547−0.1299, without significantly difference between in endometriosis and controls (P≫0.05). Conclusion: IL-8 mRNA is over expressed in peripheral blood of women with endometriosis and play key role in course of disease. The over expression of endometrium and local inflammatory reaction caused by IL-8 can be inhibited by Danazol therapy.
Starting Page	1165
Ending Page	1169
File Size	89094
Page Count	5
File Format	PDF
ISBN	9781424439287
DOI	10.1109/ITIME.2009.5236255
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-08-14
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Gynaecology Sequences Hospitals RNA Educational technology Fibroblasts Amino acids Sun Blood Diseases
Content Type	Text
Resource Type	Article

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