NDLI: Negative effect of IFN-α2b against HBV-DNA in PBMC, serum and inducement to CD25 in the patients with chronic hepatitis B

Content Provider	IEEE Xplore Digital Library
Author	Wang Jian Sun Lin Xiang Gui-ju Hu Xiao-bin
Copyright Year	2009
Description	Author affiliation: Department of Infectious Diseases, the Second Miner Hospital of Huainan, 232052, China (Xiang Gui-ju; Hu Xiao-bin) \|\| Department of Aetiology, Anhui University of Science & Technology, Huainan 232001, China (Wang Jian; Sun Lin)
Abstract	Objective: To study the effect of IFN-α2b on HBVDNA and inducement to CD25 of the patients with chronic hepatitis B. Methods: All of patients were divided into two groups and treated by IFN-α2b, routine medicine, respectively. The levels of HBV-DNA in PBMC and serum, and CD25 and CD25 mRNA, and anti-IFN-IgG were respectively detected by Real-time PCR, biotin-streptavidin (BSA) and ELISA. Results: After treatment for 24 and 48 weeks, the total negative rates of HBV-DNA in PBMC, serum and HBeAg were 36.36%, 39.39%, 40.91% and 42.42%, 51.52%, 53.03%, respectively. There was significant difference between in the two groups (P≪0.05~P≪0.01). The level of CD25 either in silence or in inducement was low in chronic hepatitis B. Only was 4 (6.06%) cases with anti-IFN-IgG(+) and little discrepancy between in two groups (P≫0.05). Conclusions: IFN-α2b has better effect on HBV-DNA. CD25 can be induced by IFN-α2b so that the active T cells play key role against HBVDNA in hosts. Low level of anti-IFN-IgG can be produced during the treatment.
Starting Page	1158
Ending Page	1164
File Size	110976
Page Count	7
File Format	PDF
ISBN	9781424439287
DOI	10.1109/ITIME.2009.5236254
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-08-14
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Liver diseases Hospitals Medical treatment Cardiac disease Cells (biology) Biochemistry Bone diseases Cardiovascular diseases Medical diagnostic imaging Immune system
Content Type	Text
Resource Type	Article

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