NDLI: Investigation of cortical neuronal reorganization for neuroprosthetics in monkeys

Content Provider	IEEE Xplore Digital Library
Author	Chaolin Ma Jiping He Hang Zhang
Copyright Year	2009
Description	Author affiliation: Center for Neural Interface Design and the Harrington Department of Bioengineering, Arizona State University, Tempe, USA (Chaolin Ma; Jiping He; Hang Zhang)
Abstract	Whether there is neural regeneration after spinal cord injury (SCI) is a challenging scientific and clinical research topic. Extensive research efforts have been devoted to identify effective neural repair strategies to limit further neural damages following spinal cord injury and promote axonal regeneration and sprouting for recovery of voluntary functions. However, little information or effort has been reported on how cortical control being affected by spinal cord injury and adaptation in such control due to spinal cord neural repair. With the advances in chronically implantable microelectrode arrays, the cortical neuronal activities have become accessible, which enables us to investigate the important question on possible changes in cortical neuron activity patterns. We implanted four 16-channel microelectrode arrays into two monkeys' primary motor cortical areas related to lower limb movement, and recorded cortical neuronal signals while they performed a bipedal walking on the treadmill. Comparing the neural population activity patterns from normal monkeys to that after spinal cord injury and treated with neural repair, we identified a significant increase in the synchronization among the recorded cortical neuronal population activities. This information would be critical for the development of effective and practical techniques to harness the cortical adaptation or plasticity after spinal cord injury to promote voluntary control of lower limb functions or neuroprosthetics for SCI victims who are reliant on wheelchair.
Starting Page	1
Ending Page	9
File Size	513051
Page Count	9
File Format	PDF
ISBN	9781424433155
DOI	10.1109/ICCME.2009.4906661
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-04-09
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Chaos Microelectrodes Actuators Neurons Robot control Circuits Spinal cord injury Helium Micromotors Neural prosthesis
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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