NDLI: Effects of Deep Brain Stimulation on dynamic posture shifts in Parkinson's disease

Content Provider	IEEE Xplore Digital Library
Author	Narayanan, K. Mulligan, S. Mahant, P. Samanta, J. Abbas, J.J.
Copyright Year	2009
Description	Author affiliation: Center for Adaptive Neural Systems at Arizona State University, USA (Abbas, J.J.) \|\| Codman & Shurtleff, Inc., USA (Mulligan, S.) \|\| Center for Adaptive Neural Systems in the Fulton School of Engineering at Arizona State University, Tempe, 85287 USA (Narayanan, K.) \|\| Center for Adaptive Neural Systems at Arizona State University and are with Banner Good Samaritan Medical Center, Phoenix, 85006 USA (Mahant, P.; Samanta, J.)
Abstract	Deep Brain Stimulation (DBS) of the subthalamic nucleus (STN) is now widely used to alleviate symptoms of Parkinson's disease (PD). The long-term goal is to develop a quantitative tool to facilitate selection of DBS settings in the clinic since the typical parameter selection process may not adequately consider the effects of DBS on posture control. The aim of this study was to characterize the effects of changing the stimulation amplitude of DBS on posture control in PD. A dynamic posture shift paradigm involving target acquisition was used to assess posture control in 4 PD STN-DBS subjects. Each subject was tested at 4 stimulation amplitude settings: Clinically-determined (CD) settings, moderate (approx. 70% CD), low (approx. 30% CD), and off (no stimulation). Movements of the center of pressure and the position of the pelvis were monitored and several quantitative indices were calculated. The most substantial change was reductions in the peak velocity and the average movement velocity during the initial and mid phases of movement towards the target posture. These results may be explained in terms of increased akinesia and bradykinesia in the altered stimulation conditions. Thus, the dynamic posture shift paradigm can reveal changes in posture control capabilities, as evidenced by changes in movement velocity, due to alterations in DBS stimulation settings.
Starting Page	1
Ending Page	6
File Size	492925
Page Count	6
File Format	PDF
ISBN	9781424433155
DOI	10.1109/ICCME.2009.4906651
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-04-09
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Space vector pulse width modulation Adaptive systems Parkinson's disease Satellite broadcasting Velocity control Brain stimulation PD control Pelvis Testing Biomedical engineering
Content Type	Text
Resource Type	Article

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