NDLI: System-level modeling and simulation of the cell culture microfluidic biochip ProCell

Content Provider	IEEE Xplore Digital Library
Author	Minhass, W.H. Pop, P. Madsen, J. Hemmingsen, M. Dufva, M.
Copyright Year	2010
Description	Author affiliation: Department of Micro- and Nanotechnology, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark (Hemmingsen, M.; Dufva, M.) \|\| Department of Informatics and Mathematical Modeling, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark (Minhass, W.H.; Pop, P.; Madsen, J.)
Abstract	Microfluidic biochips offer a promising alternative to a conventional biochemical laboratory. There are two technologies for the microfluidic biochips: droplet-based and flow-based. In this paper we are interested in flow-based microfluidic biochips, where the liquid flows continuously through pre-defined micro-channels using valves and pumps. We present an approach to the system-level modeling and simulation of a cell culture microfluidic biochip called ProCell, Programmable Cell Culture Chip. ProCell contains a cell culture chamber, which is envisioned to run 256 simultaneous experiments (viewed as a 16 × 16 matrix). We use an inverted fluorescence microscope to observe the experiments in real-time, allowing kinetic data analysis. We are able to automatically adjust the current experimental setup thus allowing, for the first time, conditional experiments. We propose a biochip architecture model and a comprehensive fault model that captures permanent faults occurring during chip operation. Using the proposed modeling and simulation framework, we perform an architectural level evaluation of two cell culture chamber implementations. A qualitative success metric is also proposed to evaluate chip performance in the presence of partial failures. Our results show that significant improvements in efficiency can be obtained using redundancy, providing improved chances to complete an experiment even in the presence of faults. This decreases the experiment repetition rate while increasing system productivity, saving time and reducing costs.
Starting Page	91
Ending Page	98
File Size	336989
Page Count	8
File Format	PDF
ISBN	9781424466368
e-ISBN	9782355000119
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-05-05
Publisher Place	Spain
Access Restriction	Subscribed
Rights Holder	EDA Publishing
Subject Keyword	Performance evaluation Data analysis Microscopy Laboratories Redundancy Fluid flow Fluorescence Valves Kinetic theory Microfluidics
Content Type	Text
Resource Type	Article

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