NDLI: A Micro-sequenced CMOS Model for Cell Signaling Pathway using G-Protein and Phosphorylation Cascade

Content Provider	IEEE Xplore Digital Library
Author	Hasan, S.M.R.
Copyright Year	2008
Description	Author affiliation: Center for Res. in Analog & VLSI Microsyst. dEsign (CRAVE), Massey Univ., Auckland (Hasan, S.M.R.)
Abstract	Communication between cells in multi-cellular organisms such as animals, humans and plants is essential for co-ordinating the organismic activities of fertilization, growth, survival and reproduction. This bio-chemical communication between trillions of cells in organisms can be more complex than the Internet. This paper develops a CMOS circuit model of signal reception and signal transduction within a cell in response to extra-cellular molecular signals. A micro-sequenced model has been developed where the signal transduction steps are clocked by circadian time intervals. The model converts the chemical signaling pathway into a CMOS multi-step logical transformation cascade transducing a received signal molecule into an activated cellular protein response. This modeling technique leads to understanding cellular malfunctions (diseases) in the form of logical (electrical) faults in a circuit.
Starting Page	57
Ending Page	62
File Size	529093
Page Count	6
File Format	PDF
ISBN	9781424437795
DOI	10.1109/MMVIP.2008.4749507
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-12-02
Publisher Place	New Zealand
Access Restriction	Subscribed
Rights Holder	Intl Journal of Intelligent
Subject Keyword	analog CMOS Circuits Humans Organisms Chemicals Diseases Semiconductor device modeling Proteins Animals Systems biology G-protein phosphorylation cascade Internet ATP Clocks
Content Type	Text
Resource Type	Article

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