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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Wei Sun |
| Copyright Year | 2009 |
| Description | Author affiliation: Department of Mechanical Engineering and Mechanics, Drexel University, 3141 Chestnut Street, Philadelphia, 19104, USA (Wei Sun) |
| Abstract | Tissue Engineering, the science and engineering of creating functional tissues and organs for transplantation, integrates a variety of scientific and engineering disciplines to produce physiologic “replacement parts” for the development of viable substitutes which restore, maintain or improve the function of human tissues. In recent Multi-Agency Tissue Engineering Science (MATES) Interagency Working Group [1], the field of tissue engineering has been broaden and redefined as “the use of physical, chemical, biological, and engineering processes to control and direct the aggregate behavior of cells”. In the success of tissue engineering, three-dimensional (3D) scaffolds play important roles as extra-cellular matrices onto which cells can attach, grow, and form new tissues. Modeling, design and fabrication of tissue scaffolds to meet multiple biological and biophysical requirements is always a challenge in regenerative tissue engineering. This is particularly true when designing load bearing scaffolds for bone and cartilage tissue application. In general, this type of scaffolds usually have intricate architecture, porosity, pore size and shape, and interconnectivity in order to provide the needed structural integrity, strength, transport, and ideal micro-environment for cell and tissue ingrowth. In addition, thus designed scaffolds often can only be fabricated through advanced manufacturing techniques, such as solid freeform fabrication (SFF) to manufacture complex structural architectures. |
| Starting Page | 43 |
| Ending Page | 44 |
| File Size | 106934 |
| Page Count | 2 |
| File Format | |
| ISBN | 9781424436996 |
| DOI | 10.1109/CADCG.2009.5246807 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2009-08-19 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Fabrication Design automation Biological system modeling Regeneration engineering Tissue engineering Humans Maintenance engineering Biology computing Matrices Application software |
| Content Type | Text |
| Resource Type | Article |
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