NDLI: Analyzing Effects of Intra-Uterine Cocaine Exposure on Adolescent Brain Structure with Symmetric Diffeomorphisms

Content Provider	IEEE Xplore Digital Library
Author	Avants, B.B. Hurt, H. Giannetta, J. Epstein, C.L. Shera, D. Wang, J. Gee, J.C.
Copyright Year	2006
Description	Author affiliation: University of Pennsylvania, USA (Avants, B.B.)
Abstract	Cocaine exposure (CE) nzug conzpronzise the developing brain through disruption of neural ontogeny in dopaminergic systems, erects seconda? to fetal hypoxenzia, and, perhaps, via altered cei-ebro\iascular I-eactivity. Although studies in adult cocaine addicts show decreases in gi-ay nzattel; white inattel; and fiinctional connectivity there are few investigations to date regarding intra-uterine cocaine exposure (IUCE) in young subjects. The existing literature suggests that long term CE coitsequeitces irt adolescents nzap be subtle 01- nzasked by other variables. Tlzei-efore, sensitive nzethods of analysis are needed. Here, we describe our most recent methods for deriving an optiinal pediatric atlas froin the 49 subject IUCE population invoh>edi n this study. Our nzetlzod, synznzetric nornzalization (SyN), is entirely syimnetric, in that both the pair wise registmtion and gi-oup wise I-egistmtion methods do not depend on the ordering of the input data. The method eliminates atlas selection by deriving an optiinal shape and intensity atlas fioin the data. PreliininaFy results using SyN indicate signijcant size dvfei- ewes in caudate rtuclei arid the spleniunz of the c o p i s callosunz, suggesting CE-i-elated detrinzent to the dopanzinergic and visiial systems. Fiirthernzore, we have found that, in conzparison, statistical parametric mapping (SPM) does not pi-oduce sigrti$cartt I-esults.
Starting Page	94
Ending Page	94
File Size	1413763
Page Count	1
File Format	PDF
ISBN	0769526462
DOI	10.1109/CVPRW.2006.30
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-06-17
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Brain Pediatrics Shape Statistical analysis Hospitals Scanning probe microscopy Humans Biology computing Anatomy Biomedical imaging
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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