NDLI: Accurate and quantitative studies on the MRS of metabolite concentration of human brain using LCModel at 1.5 T

Content Provider	IEEE Xplore Digital Library
Author	Shaoqiang Xu Shanshan Huo Qingchun Qiu Zhiwei Shen Zhongxian Yang Renhua Wu Yaowen Chen
Copyright Year	2012
Description	Author affiliation: Med. Coll., 2nd Affiliated Hosp., Shantou Univ., Shantou, China (Zhiwei Shen; Zhongxian Yang; Renhua Wu) \|\| Eng. Coll., Shantou Univ., Shantou, China (Yaowen Chen) \|\| Med. Coll., Shantou Univ., Shantou, China (Shaoqiang Xu; Shanshan Huo; Qingchun Qiu)
Abstract	Magnetic resonance spectroscopy (MRS) as a noninvasive technique has been widely used in medical imaging. Currently, metabolite concentrations, which could be detected by lots of softwares, are represented mainly in ratios (i.e., relative to creatine) or with absolute concentrations. In this contribution, we investigate the reliability and accuracy of absolute concentration quantified by Linear Combination of Model spectra (LCModel), and data were collected by single voxel technique (SVT) and multi-voxel technique (MVT). Ten amnestic mild cognitive impairment (aMCI) patients and one phantom were studied. In order to improve the clinic practicality of MRS, the factors affecting the accurate quantification of absolute concentration were investigated using LCModel when we used SVT. By changing the number of scans, the tendency of metabolite concentrations, standard deviation (SD) and Signal to Noise Ratio (SNR) was obtained. It was found that if the number of scans was set to be 64, the concentration of creatine, inositol, glutamate, and choline was reached to its maximum, and if the number of scans was increased, the concentration of each metabolite was nearly same as 64 times. On the other hand, with the increase of scanning times, the standard deviations of metabolite concentration decreased and the signal-to-noise ratios increased.
Starting Page	701
Ending Page	704
File Size	693203
Page Count	4
File Format	PDF
ISBN	9781467311830
e-ISBN	9781467311847
DOI	10.1109/BMEI.2012.6512996
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-10-16
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Absolute quantification 1.5T Amnestic mild cognitive impairment LCModel MRS
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Relationship of Parieto-Occipital Brain Energy Phosphate Metabolism and Cognition Using 31P MRS at 7-Tesla in Amnestic Mild Cognitive Impairment

Experimental Basis Sets of Quantification of Brain ¹H-Magnetic Resonance Spectroscopy at 3.0 T.

Comparison of LCModel and SAGE in Analysis of Brain Metabolite Concentrations-A study of Patients with Mild Cognitive Impairment.

A Pilot Study on the Cutoff Value of Related Brain Metabolite in Chinese Elderly Patients With Mild Cognitive Impairment Using MRS

Corrigendum: A Pilot Study on the Cutoff Value of Related Brain Metabolite in Chinese Elderly Patients With Mild Cognitive Impairment Using MRS

Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0T

Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0T

Clinical observation and mechanism of acupuncture on amnestic mild cognitive impairment based on the gut-brain axis: study protocol for a randomized controlled trial.

Quantitative and Qualitative Assessment of Verbal Fluency in Amnestic Mild Cognitive Impairment

Accurate and quantitative studies on the MRS of metabolite concentration of human brain using LCModel at 1.5 T

Similar Documents

Relationship of Parieto-Occipital Brain Energy Phosphate Metabolism and Cognition Using 31P MRS at 7-Tesla in Amnestic Mild Cognitive Impairment

Experimental Basis Sets of Quantification of Brain 1H-Magnetic Resonance Spectroscopy at 3.0 T.

Comparison of LCModel and SAGE in Analysis of Brain Metabolite Concentrations-A study of Patients with Mild Cognitive Impairment.

A Pilot Study on the Cutoff Value of Related Brain Metabolite in Chinese Elderly Patients With Mild Cognitive Impairment Using MRS

Corrigendum: A Pilot Study on the Cutoff Value of Related Brain Metabolite in Chinese Elderly Patients With Mild Cognitive Impairment Using MRS

Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0T

Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0T

Clinical observation and mechanism of acupuncture on amnestic mild cognitive impairment based on the gut-brain axis: study protocol for a randomized controlled trial.

Quantitative and Qualitative Assessment of Verbal Fluency in Amnestic Mild Cognitive Impairment

Accurate and quantitative studies on the MRS of metabolite concentration of human brain using LCModel at 1.5 T

Experimental Basis Sets of Quantification of Brain ¹H-Magnetic Resonance Spectroscopy at 3.0 T.