NDLI: VBM analysis of white matter volume in children with ametropic amblyopia

Content Provider	IEEE Xplore Digital Library
Author	Qinying Jiang Qian Li Mingxia Guo Wei Han Xiaohui Yin Huilan Shi
Copyright Year	2012
Description	Author affiliation: Dept. of Radiol., Tianjin Med. Univ., Tianjin, China (Qian Li; Wei Han; Xiaohui Yin; Huilan Shi) \|\| Inst. of Med. Imaging, Tianjin Med. Univ., Tianjin, China (Qinying Jiang; Mingxia Guo)
Abstract	A number of researches have studied the neurophysiological bases of amblyopia, and most of these studies focused on the gray matter alterations. For the purpose of elucidating whether there would be any changes in the white matter, a combination of high-resolution anatomic MRI and vision tests were used to compare a group of children with ametropic amblyopia and control subjects. An automated and unbiased method called voxel-based morphometry (VBM) was employed to analyze the anatomical brain images. After performing two sample t-tests, decreased white matter volume were detected in ametropic amblyopic children versus controls. The involved regions were predominantly in the occipital lobes bilaterally, and a smaller region in middle frontal lobe. It indicates that visual defects in amblyopia can influence the development of white matter.
Starting Page	387
Ending Page	390
File Size	351634
Page Count	4
File Format	PDF
ISBN	9781467311830
e-ISBN	9781467311847
DOI	10.1109/BMEI.2012.6512896
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-10-16
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	VBM white matter MRI ametropic amblyopia
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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