NDLI: The simulation of the relevance of dose and Hill coefficient to drug effect

Content Provider	IEEE Xplore Digital Library
Author	Lei Zhao Xinling Shi Jianhua Chen Yajie Liu
Copyright Year	2012
Description	Author affiliation: Sch. of Inf. Sci. & Eng., Yunnan Univ., Kunming, China (Lei Zhao; Xinling Shi; Jianhua Chen; Yajie Liu)
Abstract	Clinical trial simulation (CTS) which is the process of simulating clinical trials based on a mathematical model can facilitate analyzing the ambiguity about the dose-response. To investigate how the drug effect varies with the parameters dose and Hill coefficient (N) this study simulates a pharmacokinetic-pharmacodynamic (PK-PD) model. Based on the MATLAB software the simulations illustrated the results of the variation of the drug effect in two- and three-dimensional diagrams. It was showed that the drug effect lags behind the plasma drug concentration and with the increasing dose it doesn't always increase obviously. With the increasing value of N the maximum drug effects decrease when the doses are lower than 9 mg whereas they increase when the doses are higher than 11 mg. Results demonstrate that the relationship between parameter and drug effect can be clearly observed during the process of simulation. The diagrams are meaningful for the selection of rational doses and N in the clinical dosage regimen.
Starting Page	674
Ending Page	678
File Size	1062546
Page Count	5
File Format	PDF
ISBN	9781467311830
e-ISBN	9781467311847
DOI	10.1109/BMEI.2012.6512905
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-10-16
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	dose sigmoid Emax model simulation pharmacokinetic-pharmacodynamic model Hill coefficient
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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