NDLI: A study of cerebral glucose metabolism and hemodynamic response in schizophrenia

Content Provider	IEEE Xplore Digital Library
Author	Jing Zhang Kingwai Chu Hazlett, E.A. Buchsbaum, M.S.
Copyright Year	2011
Description	Author affiliation: Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029. USA (Jing Zhang; Kingwai Chu; Hazlett, E.A.; Buchsbaum, M.S.)
Abstract	This research investigated the relationship between regional cerebral glucose metabolism rate (rGMR) of [18F] fluorodeoxyglucose positron emission tomography (FDG-PET) and hemodynamic response of blood-oxygen-level-dependent (BOLD) fMRI in schizophrenia. An auditory prepulse-to-attention task was performed during the FDG uptake and the fMRI scan, and PET and fMRI images were obtained for 10 unmedicated schizophrenia patients and 7 healthy controls. Hemodynamic response curves were extracted from several brain regions and the area under the curve (AUC) was calculated and correlated with corresponding rGMR. The results indicated that (1) The rGMR and hemodynamic responses were significantly correlated in the frontal and temporal cortices, anterior cingulate cortex (ACC), caudate and thalamus for all subjects; (2) The patterns of the correlations are different between patients and controls. These results suggest that schizophrenia patients may have altered blood flow-metabolic processes during neuronal activities underlying attention deficits, which may be useful for early diagnosis of schizophrenia.
Starting Page	77
Ending Page	81
File Size	379164
Page Count	5
File Format	PDF
ISBN	9781424493517
e-ISBN	9781424493524
DOI	10.1109/BMEI.2011.6098316
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-10-15
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Correlation Cerebral glucose metabolism Schizophrenia Biochemistry Hemodynamics Positron emission tomography Psychiatry Sugar Hemodynamic response
Content Type	Text
Resource Type	Article

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