NDLI: Relationship of Fas, FasL, p53 and bcl-2 expressions in human non-small cell lung carcinomas

Content Provider	IEEE Xplore Digital Library
Author	Yin Li Dong Jiang Jun Zhao Jin-Feng Ge Shi-Ying Zheng
Copyright Year	2010
Description	Author affiliation: Department of Thoracic Surgery, The Tumor Hospital of Henan, Zhengzhou, Henan Province, 450008, China (Yin Li) \|\| Department of Cardio-Thoracic Surgery, The First Affiliated Hospital of Suzhou University, 215006, Jiangsu Province, China (Dong Jiang; Jun Zhao; Jin-Feng Ge; Shi-Ying Zheng)
Abstract	Lack of surface Fas expression is a main route for apoptotic resistance which is considered an important mechanism of tumorigenesis and tumor progression. Fas and FasL expressions in 110 non-small cell lung carcinomas (NSCLCs) were investigated to evaluate their roles in pulmonary carcinogenesis and to examine the clinicopathologic significance of Fas expression with its relationship with p53 and bcl-2 over-expressions. Immuno- histochemical analysis using tissue microarray demonstrated that a large proportion of NSCLC patients (60%) showed lack of membranous Fas expression. The Fas- negative cases revealed the significantly lower survival rate than Fas-positive ones. Also, the loss of Fas receptor expression was found more frequently in advanced stage and higher nodal status. FasL protein was increased in most NSCLCs (89%) compared to normal lungs. p53 and bcl-2 overexpressions showed no association with Fas expression. Conclusively, reduced membranous Fas expression as a mechanism of apoptotic resistance is considered to play an important part of the pulmonary carcinogenesis, which may predict poor survival and have a bad prognostic influence. Increased FasL expression is thought to be a basis for the immune evasion in NSCLCs. The rare bcl-2 overexpression suggests that this anti-apoptotic protein is unlikely to play a role in the apoptotic resistance of NSCLCs.
Starting Page	503
Ending Page	510
File Size	350939
Page Count	8
File Format	PDF
ISBN	9781424464951
e-ISBN	9781424464982
DOI	10.1109/BMEI.2010.5639972
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-10-16
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Antigens CD95 Carcinoma Biological tissues Carcinogenesis Non-Small- Cell Lung Proteins Hospitals FasL protein Lungs Tumors Immune system Cancer
Content Type	Text
Resource Type	Article

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