NDLI: Preclinical studies of S1 in K562 cell line and primary chronic myeloid leukemia cells shown synergistic effect with Cytosine Arabinoside Hydrochloride

Content Provider	IEEE Xplore Digital Library
Author	WenJuan Chen ChangJi Yuan ZhiChao Zhang PeiRan Xu Wei Han Le Han
Copyright Year	2010
Description	Author affiliation: Department of Anesthesiology, The First Hospital of JiLin University, Changchun, China (ZhiChao Zhang) \|\| Cancer Center, The First Hospital of JiLin University, Changchun, China (PeiRan Xu) \|\| Thoracic Surgery Treatment Center, Shaanxi Provincial Tumor Hospital, XI'AN, China (Le Han) \|\| Cancer Center, The First Hospital of JiLin University/ Shaanxi Provincial, Tumor Hospital, Changchun/ XI'AN, China (WenJuan Chen) \|\| Thoracic Surgery Treatment Center, the second hospital of jilin university, Changchun, China (Wei Han) \|\| School of Environmental & Biological Science & Technology, Dalian University of Technology, China (ChangJi Yuan)
Abstract	Purpose: Overexpression of Bcl-2 protein has been observed in most of chronic myeloid leukemia(CML), especially in aggressive and blastic phases. The aim of this study is to investigate its therapeutic potential as a novel small-molecule inhibitor of Bcl-2 for the treatment of CML. Experimental Design: S1 is a new class of potent small-molecule inhibitor acting on Bcl-2 protein. The activity of S1 was evaluated in cultured Human chronic myeloid leukemia cell line K562 and patient CML samples, Drug combination therapy using S1 with a commonly used leukemia drug was also investigated. Results: K562 cells were exposed to various concentrations of S1 for 6h, MTT experiments showed that S1 inhibit proliferation on dose-dependent manner. S1 blocked K562cells in the G1 phase of cell cycle .S1 showed a synergistic effect when combined with Cytosine Arabinoside Hydrochloride (Ara-c) in inducing K562 cell apoptosis. Furthermore, S1 down-regulated the Bcl-2 protein in K562 cell line and primary CML cells. Conclusions: These studies show substantial induce apoptosis activity of S1 as a potent Bcl-2 inhibitor, demonstrate a synergistic combination effect, and suggest a rationale for future clinical trials.
Starting Page	459
Ending Page	463
File Size	673848
Page Count	5
File Format	PDF
ISBN	9781424464951
e-ISBN	9781424464982
DOI	10.1109/BMEI.2010.5639266
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-10-16
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Proteins Drugs Inhibitors Hospitals bcl-2 Laboratories chronic myeloid leukemia Chemicals S1 Cancer synergistic effect
Content Type	Text
Resource Type	Article

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