NDLI: Mecamylamine affects cell proliferation and adhesion of lung cancer in vitro

Content Provider	IEEE Xplore Digital Library
Author	Xiaoli Ma Yun Zhao Yunshan Wang Xiuping Zhang Qian Zhou Haiji Sun Liguo An Xueping Zhang
Copyright Year	2010
Description	Author affiliation: College of Life Science, Shandong Normal University, Jinan 250014, China (Haiji Sun; Liguo An; Xueping Zhang) \|\| Medical Research and Laboratory Diagnostic Center, Jinan Central Hospital Affiliated to Shandong University, 250013, China (Xiaoli Ma; Yun Zhao; Yunshan Wang; Xiuping Zhang; Qian Zhou)
Abstract	Mecamylamine, pharmacologically, has been well characterized as a nonselective and noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). Because mecamylamine easily crosses the blood - brain barrier at relatively low doses, it has been used by several research groups over the past two decades investigating the role of central nAChRs in the etiology and treatment of various neuropsychiatric disorders. Recently, nAChRs have also been found on non-neuronal cells such as bronchial epithelium and keratinocytes, so it is necessary to investigate the antitumor activity of mecamylamine in lung cancer. In the present study, we study the effects of mecamylamine on cell proliferation and adhesion of lung cancer in vitro. The results showed that cell proliferation of lung cancer was inhibited by mecamylamine treatment in dose dependent and time dependent manners and expression of cell adhesion molecule was changed after mecamylamine treatment. These results indicate that nAChRs played important roles in cell proliferation as well as cell adhesion of lung cancer and action of mecamylamine may be effective as an augmentation pharmacotherapy for lung cancer.
Starting Page	2078
Ending Page	2080
File Size	289381
Page Count	3
File Format	PDF
ISBN	9781424464951
e-ISBN	9781424464982
DOI	10.1109/BMEI.2010.5639870
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-10-16
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	lung cancer mecamylamine Adhesives Lungs Microprocessors cell proliferation Genomics Computer architecture Biomembranes adhesion nicotinic acetylcholine receptors Cancer
Content Type	Text
Resource Type	Article

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