NDLI: Editing Bayesian Networks: A New Approach for Combining Prior Knowledge and Gene Expression Measurements for Researching Diseases

Content Provider	IEEE Xplore Digital Library
Author	Rubinstein, U. Felder, Y. Ginzbourg, N. Gurevich, M. Tuller, T.
Copyright Year	2008
Description	Author affiliation: Sch. of Comput. Sci., Tel Aviv Univ., Tel Aviv (Felder, Y.; Ginzbourg, N.; Tuller, T.) \|\| Multiple Sclerosis Center, Sheba Med. Center, Tel-Hashomer (Rubinstein, U.; Gurevich, M.)
Abstract	We describe a new approach for combining and comparing: (1) The information that gene expression measurements represent. (2) Prior biological knowledge (that is modeled as a weighted graph). Our approach includes translating the prior biological knowledge to a Bayesian Network (BN), and searching solutions with a small edit distance from that BN but with a significant better fitness to the gene expression measurements. This method can be useful for analyzing gene expression of patients whose regulatory processes are slightly different than those that are known from the literature (e.g. for healthy subjects).We demonstrate the viability of our method by analyzing synthetic and biological examples.
Starting Page	273
Ending Page	277
File Size	291162
Page Count	5
File Format	PDF
ISBN	9780769534527
DOI	10.1109/BIBM.2008.24
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-11-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Gene Expression Biological system modeling Regulatory Networks Biomedical measurements Gene expression Data mining Diseases Prior Biological Knowledge Proteins Computer science Bayesian Networks Bayesian methods Biology computing Bioinformatics of Diseases Bioinformatics
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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