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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Matula, T.J. Swalwell, J. Juan Tu Weicheng Cui Weizhong Chen |
| Copyright Year | 2011 |
| Description | Author affiliation: Dept. of Phys., Nanjing Univ. Nanjing, Nanjing, China (Juan Tu; Weicheng Cui; Weizhong Chen) || Center for Ind. & Med. Ultrasound CIMU, Univ. of Washington, Seattle, WA, USA (Matula, T.J.; Swalwell, J.) |
| Abstract | Experiments were performed to size, count, and obtain shell parameters for individual ultrasound contrast microbubbles using a modified flow cytometer. Light scattering was modeled with Mie theory and applied to calibration beads to calibrate the system. The size distribution and population were measured directly from the flow cytometer. The shell parameters (shear modulus and shear viscosity) were quantified at different acoustic pressures by fitting microbubble response data to a bubble dynamics model. The size distribution of the contrast agent microbubbles is consistent with manufacturer specifications. The shell shear viscosity increases with increasing equilibrium microbubble size, and decreases with increasing shear rate. The observed trends are independent of driving pressure amplitude. The shell elasticity does not vary with microbubble size. The results suggest that a modified flow cytometer can be an effective tool to characterize the physical properties of microbubbles, including size distribution, population, and shell parameters. |
| Sponsorship | IEEE Ultrasonics, Ferroelectrics Frequency Control Soc. |
| Starting Page | 156 |
| Ending Page | 159 |
| File Size | 987445 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781457712531 |
| ISSN | 19485727 |
| e-ISBN | 9781457712524 |
| DOI | 10.1109/ULTSYM.2011.0039 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2011-10-18 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Ultrasonic imaging Acoustics Viscosity Elasticity Scattering Mathematical model Low pass filters characterization microbubbles flow cytometry ultrasound contrast agents |
| Content Type | Text |
| Resource Type | Article |
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