NDLI: Quantitative intravascular ultrasound. Demonstration using a novel site targeted acoustic contrast agent

Content Provider	IEEE Xplore Digital Library
Author	Christy, D.H. Wallace, K.D. Lanzat, G.M. Holland, M.R. Hall, C.S. Scott, M.J. Cacheris, W.P. Gaffney, P.J. Miller, J.G. Wickline, S.A.
Copyright Year	1995
Description	Author affiliation: Div. of Cardiology, Jewish Hospital, St. Louis, MO, USA (Christy, D.H.)
Abstract	The authors' goal is to apply the techniques of quantitative ultrasonic tissue characterization to intravascular ultrasound. They have developed a system to acquire radio frequency ultrasonic signals from a modified commercially available intravascular ultrasound scanner. This system incorporates a novel method of acoustic signal calibration. Experiments have been completed demonstrating the ability to make repeatable measurements of frequency-averaged backscattered power. In order to test and evaluate this system, intravascular ultrasound was used to characterize the enhancement of backscattered power from clot specifically targeted with an acoustic contrast agent recently developed in the authors' laboratory. The agent has the unique physical attribute of low inherent echogenicity in suspension, while attaining high acoustic reflectivity when bound to a biologic surface or to itself. Clots from canine plasma were formed in vitro on nitrocellulose membranes. Clots were incubated with either a clot-specific (n=2) or a clot-nonspecific (n=2) contrast emulsion. Specimens were imaged with a 30 MHz intravascular ultrasonic catheter. Radio frequency signals backscattered from the clots were acquired, gated, and their power spectra obtained by FFT. Frequency-averaged power backscattered from the clots exposed to clot-specific contrast exceeded that from clots exposed to clot-nonspecific contrast by 5.6/spl plusmn/0.7 dB (/spl plusmn/SD,p<0.05). These data demonstrate the capability of this system to determine quantitative indexes of backscatter and suggest the feasibility of applying quantitative ultrasonic tissue characterization in clinical intravascular ultrasound.
Starting Page	1125
Ending Page	1128
File Size	271371
Page Count	4
File Format	PDF
ISBN	0780329406
ISSN	10510117
DOI	10.1109/ULTSYM.1995.495758
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1995-11-07
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Ultrasonic imaging Radio frequency RF signals Calibration Acoustic measurements Power measurement Frequency measurement Ultrasonic variables measurement Acoustic testing System testing
Content Type	Text
Resource Type	Article

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