NDLI: Decoupling Control of Intracranial Temperature and Pressure for Brain Hypothermia Treatment

Content Provider	IEEE Xplore Digital Library
Author	Lu Gaohua Kimura, H.
Copyright Year	2006
Description	Author affiliation: Bio-Mimetic Res. Center of Riken, Nagoya (Lu Gaohua; Kimura, H.)
Abstract	As brain hypothermia treatment (BHT) consists of simultaneous management of various vital physiological functions, a decoupling control of intracranial temperature (ICT) and pressure (ICP) is proposed to give hints on this systemic medicine. For theoretical simulation, a transfer function matrix is identified to linearly approximate the characteristic interrelationships between medical treatments (ambient cooling and diuretic administration) and the vital signs (ICT and ICP) of an integrated model, which is developed to simulate the thermodynamics, hemodynamics and the pharmacokinetics of a patient under BHT. It is shown that ICT and ICP of the model can be simultaneously regulated by a single PID controller of ambient cooling and another of diuretic administration, whereas the decoupler effectively establishes hypothermic decompression, reduces the diuretic administration and improves ICP management.
Starting Page	524
Ending Page	529
File Size	2586032
Page Count	6
File Format	PDF
ISBN	1424400996
DOI	10.1109/ICSMC.2006.384437
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-10-08
Publisher Place	Taiwan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Pressure control Temperature control Medical control systems Medical treatment Medical simulation Cooling Control systems Brain modeling Transfer functions Linear approximation
Content Type	Text
Resource Type	Article

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