NDLI: Investigation of difference of origin of ROS generated in a cell by frequency components of pulsed electric field

Content Provider	IEEE Xplore Digital Library
Author	Minamitani, Y. Kobayashi, Y. Kageyama, R.
Copyright Year	2015
Description	Author affiliation: Grad. Sch. of Sci. & Eng., Yamagata Univ., Yamagata, Japan (Minamitani, Y.; Kobayashi, Y.; Kageyama, R.)
Abstract	High voltage short pulse can provide new biological and medical applications for example sterilization and cancer treatment. When the pulsed voltage is applied to a cell, the constituent of the cell that the voltage is applied to is different at frequency of the voltage. When low frequency voltage is applied to the cell, the voltage concentrates to the cell membrane. It is presumed that the pulsed electric field with low frequency component causes breakdown of the cell membrane. If the breakdown occurs in the cell membrane, ROS (Reactive Oxygen Species) must be detected in the cell. On the other hand, when high frequency voltage is applied to the cell, the voltage concentrates to the inside of the cell. If the voltage is enough high, it causes cytotoxicity. In this case, also, ROS generated at a mitochondria must be detected in the cell. Eventually ROS is detected in both cases. Therefore, we have investigated the frequency characteristic of origin of ROS generated in the cell by frequency components of pulsed electric field. This investigation will be an evidence that the breakdown occurs in the cell membrane by pulsed electric field.
Starting Page	1
Ending Page	4
File Size	556055
Page Count	4
File Format	PDF
e-ISBN	9781479984039
DOI	10.1109/PPC.2015.7296783
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-05-31
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Electric fields Biomembranes Gases Calcium Fluorescence Discharges (electric)
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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