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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Seong-O Choi Jung-Hwan Park Yoonsu Choi Yeuchun Kim Gill, H.S. Yong-Kyu Yoon Prausnitz, M.R. Allen, M.G. |
| Copyright Year | 2005 |
| Description | Author affiliation: Sch. of Electr. & Comput. Eng., Georgia Inst. of Technol., Atlanta, GA, USA (Seong-O Choi; Jung-Hwan Park; Yoonsu Choi) |
| Abstract | We have designed and fabricated a microneedle array with electrical functionality with the final goal of electroporating skin's epidermal cells to increase their transfection by DNA vaccines. The microneedle array was made of polymethylmethacrylate (PMMA) by micromolding technology from a master PDMS mold, followed by metal deposition, patterning using laser ablation, and electrodeposition. This microneedle array possessed sufficient mechanical strength to penetrate human skin in vivo and was also able to electroporate red blood cells as an in vitro model to demonstrate cell membrane permeabilization. |
| Sponsorship | Korean Sensors Soc |
| Starting Page | 1513 |
| Ending Page | 1516 |
| File Size | 795060 |
| Page Count | 4 |
| File Format | |
| ISBN | 0780389948 |
| DOI | 10.1109/SENSOR.2005.1497371 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2005-06-05 |
| Publisher Place | South Korea |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Skin Epidermis DNA Vaccines Optical arrays Laser ablation Laser modes Humans In vivo Red blood cells |
| Content Type | Text |
| Resource Type | Article |
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