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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Pal, G. Sajjadi, A. Mitra, K. Grace, M.S. |
| Copyright Year | 2009 |
| Description | Author affiliation: Department of Mechanical & Nuclear Engineering, The Pennsylvania State University, University Park, 16802, USA (Pal, G.) || Department of Mechanical & Aerospace Engineering, Florida Institute of Technology, Melbourne, 32901, USA (Sajjadi, A.; Mitra, K.) || Department of Biological Sciences, Florida Institute of Technology, Melbourne, 32901, USA (Grace, M.S.) |
| Abstract | The objective of this paper is to perform a comprehensive experimental and numerical analysis of the short pulse laser interaction with tissue medium with the goal of tumor / cancer diagnostics. For a short pulse laser source, the shape of the output signal is a function of the optical properties of the medium and hence the scattered temporal optical signal helps in understanding of the medium characteristics. In this paper the scattered reflected optical signals from the tissue medium are modeled using the transient radiative transport equation (RTE) solved by the discrete ordinates technique. In vivo imaging was performed on anaesthetized rats with tumorogenic agents injected inside skin tissues and on anaesthetized mouse with mammary tumors. The numerical results are compared with the experimental data to validate the model and demonstrate the feasibility of the time-resolved technique in detecting tumors in animal model. |
| Starting Page | 1609 |
| Ending Page | 1613 |
| File Size | 242025 |
| Page Count | 5 |
| File Format | |
| ISBN | 9781424458257 |
| ISSN | 10586393 |
| e-ISBN | 9781424458271 |
| DOI | 10.1109/ACSSC.2009.5470177 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2009-11-01 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Laser modes Radiation detectors Neoplasms Animals Optical scattering Numerical analysis Optical pulses Cancer Optical pulse shaping Shape |
| Content Type | Text |
| Resource Type | Article |
| Subject | Signal Processing Computer Networks and Communications |
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