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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Vereb, H. Alfeeli, B. Dietrich, A. Agah, M. |
| Copyright Year | 2011 |
| Description | Author affiliation: Department of Civil and Environmental Engineering, Virginia Tech, Blacksburg, USA (Vereb, H.; Dietrich, A.) || VT MEMS Lab, Department of Electrical and Computer Engineering, Virginia Tech, Blacksburg, USA (Alfeeli, B.; Agah, M.) |
| Abstract | This paper introduces, for the first time, divinylbenzene (DVB) packed microfabricated preconcentrators (µPCs) for the analysis of volatile organic compounds in breath. The 7 mm × 7 mm × 0.35 mm microcavity performance was compared to commercial solid phase microextraction (SPME) fibers commonly used in extraction and concentration of analytes in breath. The device successfully concentrated lipid oxidation products in human breath and allowed for gas chromatography analysis that distinguished control breath from treated breath produced after the subject was dosed with iron to stimulate production of lipid oxidation products that are often used as biomarkers for disease. The µPC was superior to SPME fibers incorporating the same adsorbent material and was able to detect standard compounds loaded at nanomolar (nM) concentrations. |
| Starting Page | 1237 |
| Ending Page | 1240 |
| File Size | 761406 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781424492909 |
| ISSN | 19300395 |
| e-ISBN | 9781424492893 |
| DOI | 10.1109/ICSENS.2011.6127388 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2011-10-28 |
| Publisher Place | Ireland |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Lipidomics Oxidation Digital video broadcasting Optical fiber devices Compounds Iron Standards |
| Content Type | Text |
| Resource Type | Article |
| Subject | Electrical and Electronic Engineering |
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