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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Franks, W. Heer, F. Tosatti, S. Hafizovic, S. Seif, P. Textor, M. Hierlemann, A. |
| Copyright Year | 2004 |
| Description | Author affiliation: Phys. Electron. Lab., Eidgenossische Tech. Hochschule, Zurich, Switzerland (Franks, W.; Heer, F.) |
| Abstract | Bioelectronic devices for the investigation of electrogenic cells either comprise advanced system architectures (K. Gilchrist et al., Biosens. & Bioelects., vol. 16, pp. 557-564, 2001) or patterned structures for guided cell growth (S. Rohr et al., Pflugers Arch., vol. 446, pp. 125-32, 2003). Here we present an approach to combine a CMOS biosensor with sophisticated surface patterning for guided cell growth. The CMOS biosensor comprises a 128-electrode array, with on-chip stimulation and recording capabilities. An engineered surface for high-contrast protein adsorption and cell attachment has been developed. Surface functionalization is based on selective molecular assembly patterning (SMAP) (R. Michel et al., Langmuir, vol. 18, pp. 3281-3287, 2002) thus obviating the need for additional lithographic steps. An amine-terminated self-assembled monolayer is used for cell adhesion at each electrode site. A protein-repellent grafted copolymer, poly(L-lysine)-graft-poly(ethylene glycol) (PLL-g-PEG), is used to render the surrounding silicon oxide resistant to protein adsorption. |
| Starting Page | 1014 |
| Ending Page | 1017 |
| File Size | 766067 |
| Page Count | 4 |
| File Format | |
| ISBN | 0780386922 |
| DOI | 10.1109/ICSENS.2004.1426345 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2004-10-24 |
| Publisher Place | Austria |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Biosensors CMOS technology Cardiology Sensor arrays Gold Silicon Proteins Glass Adhesives Electrodes |
| Content Type | Text |
| Resource Type | Article |
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