NDLI: Three-dimensional magnetic assembly of alginate microfibers using microfluidic “printing” method

Content Provider	IEEE Xplore Digital Library
Author	Tao Sun Qiang Huang Qing Shi Huaping Wang Nakajima, M. Fukuda, T.
Copyright Year	2015
Description	Author affiliation: Dept. of Micro-Nano Syst. Eng., Nagoya Univ., Nagoya, Japan (Nakajima, M.) \|\| Sch. of Mechatronical Eng., Intell. Robot. Inst., Beijing, China (Tao Sun; Qiang Huang; Qing Shi; Huaping Wang) \|\| Fac. of Sci. & Eng., Meijo Univ., Nagoya, Japan (Fukuda, T.)
Abstract	Due to the poor controllability in hydrogels, Hydrogels-based assembly to form larger 3D complex shapes is still a big challenge. In this paper, we have reported a novel “bottom-up” method to fabricate three-dimensional (3D) magnetic alginate microfibers (MAMs) assemblies with complex shapes. Specifically, Alginate microfibers encapsulating $Fe_{3}O_{4}$ magnetic nanoparticles (MNs) and fibroblasts (NIH/3T3) have been spun using microfluidic method with “pinch-off” scheme. Experimental results show that the MAMs can respond quickly to the magnetic field, enabling their enhanced controllability. The magnetic assembly system is constructed by PDMS microfluidic device, 3D supporting model adhered on the bottom surface of dish filled with deionized water and magnet. The microfluidic “printing“ and magnetic deposition in magnetic assembly process are experimentally demonstrated, respectively. Because of magnetic field, the complex assembly shapes can be fabricated just by moving the microfluidic device in a plane. To match well with the shape of supporting model and to keep a stable assembly structure, the secondary cross-linking method is employed. From the LIVE/DEAD assay, cells can survive well during the magnetic assembly process.
Starting Page	2698
Ending Page	2703
File Size	976588
Page Count	6
File Format	PDF
e-ISBN	9781479969234
DOI	10.1109/ICRA.2015.7139564
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-05-26
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Assembly Microfluidics Printing Shape Spinning Magnetic resonance imaging Three-dimensional displays
Content Type	Text
Resource Type	Article

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