NDLI: Effect of measurement uncertainty on region of interest based and parametric binding potential estimates for the high resolution research tomograph (HRRT)

Content Provider	IEEE Xplore Digital Library
Author	Sossi, V. Blinder, S. Rahmim, A. Dinelle, K. Cheng, K.J.-C. Lidstone, S.C.
Copyright Year	2007
Description	Author affiliation: Univ. of British Columbia (UBC), Vancouver (Sossi, V.; Blinder, S.)
Abstract	High resolution Positron Emission Tomography (PET) imaging leads to very small pixel sizes. Generally the increase in resolution is not paralleled by a corresponding increase in sensitivity which may cause the count density per voxel to be low. Here we are exploring how the statistical quality of the data acquired with the high resolution research tomograph (HRRT) influences the accuracy of the determination of the binding potential (BP) for typical human studies performed with $^{11}middotC-raclopride.$ Susceptibility to noise was tested for 3 modelling approaches: the Logan graphical model, the simplified reference tissue method (RTM) and the delayed ratio method (DRM). For each approach BP was calculated on a region of interest (ROI) and voxel basis (parametric maps). Using a method based on experimentally defined replicas of time activity curves (TACs) representative of those obtained in human scans we found that for this tracer the contribution of the statistical noise to the BP determination is ~ 5-8 % when the TACs are evaluated on an ROI basis (either ROI TACs used as input, or ROI placed on the BP parametric image) and 9-12 % when calculated on a single pixel basis. The Logan approach was found to suffer from a considerable bias due to statistical noise when the BP was calculated on a single pixel basis, while RTM and DRM showed no such bias. Overall, for this tracer and these scanning conditions the RTM proved to be the least sensitive to statistical noise in the data.
Starting Page	4539
Ending Page	4542
File Size	210600
Page Count	4
File Format	PDF
ISBN	9781424409228
ISSN	10957863
DOI	10.1109/NSSMIC.2007.4437120
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-10-26
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Measurement uncertainty Positron emission tomography Pixel Humans Image resolution High-resolution imaging Signal to noise ratio Testing Graphical models Delay
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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