NDLI: Difference imaging of inter- and intra-ictal SPECT images for the localization of seizure onset in epilepsy

Content Provider	IEEE Xplore Digital Library
Author	Hahn, D. Daum, V. Hornegger, J. Bautz, W. Kuwert, T.
Copyright Year	2007
Description	Author affiliation: Friedrich-Alexander-Univ. of Erlangen-Nuremberg (FAU), Erlangen (Hahn, D.; Daum, V.; Hornegger, J.)
Abstract	The comparison of inter- with intra-ictal SPECT images plays an important role during the diagnosis and treatment of epilepsy patients. Although there is already commercial software available to address this problem using complex clinical workflows, this article describes a different way of looking at this issue. During the examination various issues arise from differing tracer concentrations, patient movement between the acquisitions at different times and also the lack of morphological information. The goal of the presented work is therefore to present an approach that is on the one hand easy to use for the physician and on the other hand both reliable and robust enough to cope with the previously mentioned challenges. The proposed algorithm introduces methods that have already been applied successfully in digital subtraction angiography (DSA). The work comprises of several steps for the intensity normalization, image registration, difference imaging and the incorporation of an MR image for the spatial localization. As a result, information is provided about differences within the cerebral blood flow (CBF) and active brain areas between the intra- and inter-ictal states. Very new to the field of SPECT brain imaging is the application of non-rigid registration techniques. This helps to drastically reduce the artifacts within the difference images due to a bias of the standard rigid registration. Acquired results from a collective of 11 patients show that this additional feature helps to further improve the image quality.
Starting Page	4331
Ending Page	4335
File Size	1003644
Page Count	5
File Format	PDF
ISBN	9781424409228
ISSN	10957863
DOI	10.1109/NSSMIC.2007.4437074
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2007-10-26
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Epilepsy Brain Surgery Angiography Nuclear and plasma sciences Medical treatment Robustness Image registration Blood flow Image quality nonrigid registration Index Terms SPECT epilepsy difference subtraction rigid registration
Content Type	Text
Resource Type	Article

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