NDLI: An evaluation of the effect of partial-septa on detection of small lesions in brain phantom study using MDAPET camera

Content Provider	IEEE Xplore Digital Library
Author	Baghaei, H. Wong, W.-H. Uribe, J. Li, H. Wang, Y. Xing, T. Ramirez, R. Xie, S. Kim, S. Zhang, Y.
Copyright Year	2004
Description	Author affiliation: M.D. Anderson Cancer Center, Texas Univ., Houston, TX (Baghaei, H.; Wong, W.-H.; Uribe, J.; Li, H.; Wang, Y.; Xing, T.; Ramirez, R.; Xie, S.; Kim, S.; Zhang, Y.)
Abstract	We investigated the effect of partial-septa on detection of small lesions embedded into the Hoffman brain phantom using a high resolution PET camera. Three-dimensional (3D) positron emission tomography (PET) acquisition in comparison to two-dimensional (2D) PET acquisition improves the sensitivity of the system at the cost of higher random and scatter coincidence contributions. A partial-septa system, in which full ring septa are inserted between only some of the detector rings, allowing "partial" 3D acquisition may provide a better alternative than the 2D acquisition and full 3D acquisition for reducing the scatter and random coincidence with less sensitivity loss. We used the MDAPET camera to detect small lesions in brain images obtained from the scan of the 3D Hoffman brain phantom with three embedded small lesion phantoms with diameters of 3, 5, and 8.6 mm. To include the effect of background from activity outside the FOV, a large cylindrical uniform phantom with diameter of 21.5 cm filled with lower activity was placed near the Hoffman brain phantom. Data were acquired in three separate scans for 3 phantoms: (1) the large uniform cylindrical phantom; (2) the Hoffman brain phantom; (3) the 3 small lesions embedded in brain phantom. For scan of each phantom, the other phantoms were filled only with water. For lesions, data were collected for several standard uptake values (SUVs) as activity decayed. The three sets of data were selectively combined to generate the sinograms for the desired SUVs. In partial-septa configurations, the white matter regions of the brain images had lower counts and the images visually looked better than no-septa images. Images taken in the partial-septa configuration had slightly higher contrast
Starting Page	3121
Ending Page	3125
File Size	1454506
Page Count	5
File Format	PDF
ISBN	0780387007
ISSN	10823654
e-ISBN	0780387015
DOI	10.1109/NSSMIC.2004.1466342
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2004-10-16
Publisher Place	Italy
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Lesions Imaging phantoms Cameras Positron emission tomography Scattering Detectors Brain Costs Cancer Crystals
Content Type	Text
Resource Type	Article

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