NDLI: Monte Carlo evaluation of quantitation in simultaneous Tc-99m/I-123 brain SPECT using constrained spectral factor analysis

Content Provider	IEEE Xplore Digital Library
Author	El Fakhri, G. Moore, S.C. Kijewski, M.F. Maksud, P. Todd-Pokropek, A.
Copyright Year	2000
Description	Author affiliation: Harvard Med. Sch., Boston, MA, USA (El Fakhri, G.)
Abstract	Simultaneous imaging of Tc-99m and I-123 has important applications for brain imaging but is hindered by crosstalk between the two radionuclides. Monte Carlo simulations of 15 different dual-isotope studies were performed using a digital brain phantom. Several physiologic Tc-99m and I-123 uptake patterns were modeled in the brain structures. Spectral factor analysis (SFA) using constraints on the primary spectra was performed on projections to correct for crosstalk from both scattered and unscattered photons. The accuracy of reconstructed pixel values, using filtered-backprojection, within several brain structures was compared to that obtained with an energy windowing method (WSA). In I-123 images, mean bias was close to 10% in all structures for SFA and between 14% (in the caudate nucleus) and 25% (in the cerebellum) for WSA. Tc-99m activity was overestimated by 35% in the cortex and 53% in the caudate nucleus with WSA, but by less than 9% in all structures with SFA. SFA performed well even in the presence of high-energy I-123 photons; good accuracy was attained by incorporating the contamination into the model as a priori information. SFA is a promising approach to correct for crosstalk in simultaneous Tc-99m/I-123 SPECT.
Starting Page	1392
Ending Page	1396
File Size	526210
Page Count	5
File Format	PDF
ISBN	0780356969
ISSN	10823654
DOI	10.1109/NSSMIC.1999.842815
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1999-10-24
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Monte Carlo methods Crosstalk Brain modeling Single photon emission computed tomography Imaging phantoms Spectral analysis Performance analysis Electromagnetic scattering Particle scattering Image reconstruction
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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