NDLI: Quantifying cerebral PET with FDG using dynamic internal carotid arteries imaging

Content Provider	IEEE Xplore Digital Library
Author	Trebossen, R. Bendriem, B. Ribeiro, M.-J. Sarazin, M. Strul, D. Dupont, S. Semah, F. Remy, P.
Copyright Year	1999
Description	Author affiliation: CEA, SHFJ, Orsay, France (Trebossen, R.)
Abstract	The improvement of the PET sensitivity and resolution allows the measurement of the input function using dynamic scanning of the internal carotid arteries. Five subjects were scanned on an ECAT EXACT HR+ with the following sequence (number/spl times/length in seconds): 12/spl times/10, 2/spl times/30, 2/spl times/ 150, 3/spl times/300, 1/spl times/600, 1/spl times/1200 and 1/spl times/150. The scan started with the injection of the 18-FDG (168 MBq in average for the 5 subjects). The latter scan was used to calculate rCMRglc images with the autoradiographic model using the 4 "PHELPS constants". A plasma input function was measured in a radial artery. Venous samples were also taken 5 minutes after the injection at the same rate as the arterial samples (venous function). The effects of the limited resolution on the carotid measurements were corrected using geometrical factors computed from each MRI registered to the PET images. The carotid input function was then obtained after correction for blood to plasma difference using each venous function. The relative differences between the rCMRglc values calculated with an input function measured in the carotid and the radial arteries were 6%, 2%, 27%, 20%, and 8% respectively for the 5 subjects. In conclusion, for tracer modelling sensitive to the integral of the input function (such as FDG modelling), this method is adequate for quantification.
Starting Page	1737
Ending Page	1740
File Size	331464
Page Count	4
File Format	PDF
ISBN	0780350219
ISSN	10823654
DOI	10.1109/NSSMIC.1998.773875
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1998-11-08
Publisher Place	Canada
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Positron emission tomography Carotid arteries Magnetic resonance imaging Plasma measurements Blood Spatial resolution Image sampling Delay Protocols Image resolution
Content Type	Text
Resource Type	Article

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