NDLI: Methods for the correction of vascular artifacts in PET O-15 water brain mapping studies

Content Provider	IEEE Xplore Digital Library
Author	Chen, K. Reiman, E.M. Lawson, M. Yun, L.-S. Bandy, D. Palant, A.
Copyright Year	1996
Description	Author affiliation: Dept. of Radiol., Arizona Univ., Tucson, AZ, USA (Chen, K.)
Abstract	While positron emission tomographic (PET) measurements of regional cerebral blood flow (CBF) can be used to map regions of the brain that are involved in normal and pathological human behaviors, measurements in the anteromedial temporal lobe can be confounded by the combined effects of radiotracer activity in neighboring arteries and partial volume averaging. The authors now describe two alternative methods for addressing this potential confound. One method utilizes the early frames of a dynamic PET study, while the other method utilizes a coregistered magnetic resonance image (MRI) to characterize the vascular region-of-interest (ROI). Both methods subsequently assign a common value to each pixel in the vascular ROI. To simulate the vascular artifact, four dynamically acquired PET, O-15 water scans in the same subject during the same behavioral state were used to compute 4 vascular images (0-60 s after radiotracer administration) which included vascular activity and 4 control images (20-80 s after radiotracer administration) which did not. t-score maps were used to characterize regional blood flow differences related to vascular activity before and after the application of each vascular artifact-correction method. Both methods eliminated the observed differences in vascular activity, as well as the vascular artifact observed in the anteromedial temporal lobes.
Starting Page	1307
Ending Page	1310
File Size	456806
Page Count	4
File Format	PDF
ISBN	078033180X
DOI	10.1109/NSSMIC.1995.510498
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1995-10-21
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Positron emission tomography Fluid flow measurement Volume measurement Blood flow Temporal lobe Radioactive decay Pathology Humans Anthropometry Arteries
Content Type	Text
Resource Type	Article

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