NDLI: Absolute radionuclide concentration measurement using maximum likelihood expectation maximization iterative reconstruction, attenuation and scatter correction

Content Provider	IEEE Xplore Digital Library
Author	Pretorius, P.H. van Aswegen, A. Lotter, M.G.
Copyright Year	1994
Description	Author affiliation: Dept. of Biophys., Univ. of the Orange Free State, Bloemfontein, South Africa (Pretorius, P.H.; van Aswegen, A.; Lotter, M.G.)
Abstract	The aim of this study was to evaluate the accuracy with which radionuclide concentration could be measured after implementation of the channel ratio (CR) scatter correction method and incorporation of transmission coefficients into a Maximum Likelihood Expectation Maximisation iterative reconstruction algorithm. A water filled thorax phantom containing a liver insert and a variable spleen volume was used to simulate different clinical situations. An uncollimated Co-57 sheet source was used to obtain attenuation matrices. All emission data were acquired in two 10% energy windows straddling the photopeak. Planar and SPECT sensitivities were determined. After scatter correction was performed data were firstly reconstructed using the measured attenuation matrices and secondly using the good geometry attenuation coefficient for water. Radionuclide concentration with the attenuation matrix using 64 projections varied between 48.9%/spl plusmn/3.1% (49.6%/spl plusmn/3.1%) and 76.5%/spl plusmn/3.0% (76.5%/spl plusmn/3.2% when 25 and (50) iterations were used. The inaccuracy of the results obtained with the implementation of the attenuation matrix from the transmission tomogram is due to the effective attenuation coefficients used in conjunction with the scatter compensation method. Results obtained with the attenuation coefficient of water varied between 70.1%/spl plusmn/3.1% (70.8%/spl plusmn/3.0%) and 103.2%/spl plusmn/3.5% (103.3%/spl plusmn/3.4%). The influence of volume and concentration is clearly demonstrated. Edge detection plays an important role in the accuracy of concentration calculations.
Starting Page	1701
Ending Page	1705
File Size	514230
Page Count	5
File Format	PDF
ISBN	0780325443
DOI	10.1109/NSSMIC.1994.474736
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1994-10-30
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Attenuation Transmission line matrix methods Scattering Chromium Maximum likelihood detection Iterative methods Reconstruction algorithms Thorax Imaging phantoms Liver
Content Type	Text
Resource Type	Article

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