NDLI: Pinhole SPECT for imaging In-111 in the head

Content Provider	IEEE Xplore Digital Library
Author	Johnson, E.L. Jaszczak, R.J. Wang, H. Greer, K.L. Coleman, R.E.
Copyright Year	1994
Description	Author affiliation: Dept. of Cell Biol., Duke Univ. Med. Center, Durham, NC, USA (Johnson, E.L.; Jaszczak, R.J.; Wang, H.; Greer, K.L.; Coleman, R.E.)
Abstract	With the development of targeted radiotherapy techniques, quantitation of radionuclides that emit high energy photons (>140 keV) by gamma camera scintigraphy has become increasingly important in external imaging applications. The radionuclide In-111 (171 and 245 keV) has been used experimentally with monoclonal antibodies and receptor specific pharmaceuticals to obtain pre-treatment information for various types of brain tumors. Conventional protocols for imaging In-111 utilize parallel-hole collimators designed for medium energy (ME) applications. The performance of ME collimators suffers from decreased spatial resolution and/or sensitivity. Septal penetration can also lead to image degradation. Pinhole collimation can offer improved spatial resolution and/or sensitivity compared with ME collimators when imaging In-111 in objects the size of the head or smaller, especially when restricting the field-of-view to regions near the central plane. Simulation and experimental phantom studies have been used to investigate pinhole SPECT for imaging In-111 in the head. Chang attenuation and dual-window scatter subtraction compensation methods have been evaluated for potential accuracy in pinhole geometry. Results have shown improved image quality with pinhole collimation with a /spl les/15% quantitative accuracy in phantom studies. The authors demonstrate that pinhole SPECT is a viable alternative to ME collimator imaging of In-111 in objects the size of the head.
Starting Page	1888
Ending Page	1892
File Size	502007
Page Count	5
File Format	PDF
ISBN	0780325443
DOI	10.1109/NSSMIC.1994.474697
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1994-10-30
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Head Collimators Optical imaging Spatial resolution Imaging phantoms Single photon emission computed tomography Cameras Pharmaceuticals Neoplasms Protocols
Content Type	Text
Resource Type	Article

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