NDLI: Acoustic microstreaming for biological sample mixing enhancement

Content Provider	IEEE Xplore Digital Library
Author	Liu, R.H. Jianing Yang Pindera, M.Z. Athavale, M. Grodzinski, P.
Copyright Year	2002
Description	Author affiliation: Microfluidics Lab., Motorola Labs., Tempe, AZ, USA (Liu, R.H.; Jianing Yang)
Abstract	A mixing technique based on bubble-induced acoustic microstreaming principle was developed. A mixer consists of a piezoelectric disk that is attached to a reaction chamber, which has a set of air bubbles with desirable size trapped in the. solution. Fluidic experiments showed that air bubbles resting on a solid surface and set into vibration by the sound field generated circulatory flows, resulting in global convection flows and thus rapid mixing. The time to fully mix a 100 /spl mu/L chamber is significantly reduced from hours (diffusion-only) to tens of seconds. CFD modeling showed that the induced flowfield and thus degree of mixing strongly depends on bubble positions. Immuno-magnetic cell capture experiments showed acoustic microstreaming provided efficient mixing of bacterial cell (E. coli K12) matrix suspended in blood with magnetic capture beads, resulting highly effective immuno-magnetic cell capture. Bacterial viability assay experiments showed that acoustic microstreaming has a relatively low shear strain field since the blood cells and bacteria remained intact after mixing: Acoustic microstreaming has many advantages over most existing chamber micromixing techniques, including simple apparatus, ease of implementation, low power consumption (2 mW), and low cost.
Starting Page	545
Ending Page	550
File Size	820883
Page Count	6
File Format	PDF
ISBN	0780374800
DOI	10.1109/MMB.2002.1002406
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-05-02
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Microorganisms Immune system Blood Cells (biology) Solids Computational fluid dynamics Magnetic levitation Magnetic field induced strain Energy consumption Costs
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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