NDLI: Active microelectronic DNA arrays for genomic and nanofabrication applications

Content Provider	IEEE Xplore Digital Library
Author	Heller, M.J.
Copyright Year	2002
Description	Author affiliation: Dept. of Bioeng., California Univ., San Diego, La Jolla, CA, USA (Heller, M.J.)
Abstract	Microelectronic DNA arrays have been developed for point mutation, single nucleotide polymorphism (SNP), short tandem repeats (STRs) and gene expression analysis. In addition to a variety of molecular biology and genomic research applications, such devices will also be used for infectious disease detection, genetic and cancer diagnostics; forensic and genetic identification; on-chip DNA/RNA amplification and pharmacogenomic applications. These microelectronic array devices are able to produce defined electric fields on their surfaces that allows charged molecules and other entities to be transported to or from any test-site or microlocation on the planar surface of the device. These molecules and entities include DNA, RNA, proteins, enzymes, antibodies, cells, nanoparticles, and even micron scale semiconductor devices. Microelectronic arrays have been developed with 25, 100, 400, 1200, 1600, and 10,000 microlocations (test sites) that can range in size from 30 microns, to 80 microns. The microelectronic chip or array device is incorporated into a cartridge package that provides the electronic, optical, and fluidic interfacing. A complete instrument system provides a chip loader, fluorescent reader; and computer interface and data display screen. In addition to the genomic and diagnostic applications, microelectronic array technology may ultimately lead to nanofabrication processes for the controlled manipulation and heterogeneous integration of molecular scale, nanoscale and microscale components.
Starting Page	9
Ending Page	11
File Size	191958
Page Count	3
File Format	PDF
ISBN	0780374800
DOI	10.1109/MMB.2002.1002254
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2002-05-02
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Microelectronics DNA Genomics Bioinformatics Nanofabrication RNA Testing Optical arrays Genetic mutations Gene expression
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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