NDLI: Microfabricated silicon nanopore membranes provide continuous delivery of biopharmaceuticals

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2006 International Conference on MEMS, NANO, and Smart Systems

2005 International Conference on MEMS,NANO and Smart Systems

Proceedings. 2005 International Conference on MEMS, NANO and Smart Systems

2005 International Conference on MEMS,NANO and Smart Systems - Copyright

Conference Committee

Novel one dimensional nanostructures

The intrinsic spin Hall effect

Efficient spin injection using tunnel injectors

Spin-transfer induced switching in magnetic nanopillars

Injecting and controlling spin populations and currents in semiconductors using optically induced quantum interference effects

Instability of submicron anisotropic liquid cylinders and jets in magnetic field

On the effect of cationic surfactants in the rinse to reduce pattern collapse in high aspect ratio patterning of photoresists

A disjoining pressure isotherm for curved, interfacial boundaries

Influence of solid-liquid-liquid interactions on multiphase transport behavior in porous media

Non-invasive mapping of fluid temperature and flow in microsystems

Avery Dennison micro-nano replication capabilities for MEMS and microfluidics

A parametric study of thermal effects on the reliability of RF MEMS switches

Optimization of turn geometries in microfluidic channels

Spin polarized transport effects in III-V semiconductor heterostructures

Injecting and controlling spin populations and currents in semiconductors using optically induced quantum interference effects

Spinwaves in spintronics structures

Ferromagnetic III-V semiconductor films with high transition temperature

New trends in rough surface characterization: when the wrinkle is beautiful

Superhydrophobic behavior of a microtextured surface: a thermodynamic approach

Compositional dependence of wetting and contact angles in solid-liquid-liquid systems under realistic environments

Role of patterned surface charge heterogeneity on particle deposition

Polysilicon fatigue test-bed monitoring based on the 2nd harmonic of the device current measurement

Deformation analysis of tunable Fabry-Perot structure caused by thermal residual gradient stresses

Analysis of tip effects on the dynamic characteristics of V-shaped atomic force microscope probes

Nondestructive evaluation of MEMS devices by laser confocal measurements

Impact of nanotechnology in flat panel display industry

Stick-slip actuation of electrostatic stepper micropositioners for data storage-the /spl mu/walker

ANN modeling of micro-machined gas sensor signals

BioMEMS implants for neural regeneration after a spinal cord injury

Large deflection of a polyurethane elastomer under high electric field

Behavior of a moving droplet under electrowetting actuation in microchannel

Non-linear elastic deformations of multi-phase fluid systems

Thin film breakup by electric fields: development of microfluidic applications in deemulsification

Numerically modeled dynamic response of perfect and leaky dielectric droplets in an electric field

Design and simulation of one-port resonant- piezoresistive strain sensor

LIGA cavity resonator for K-band applications

MEMS design for fabrication

Fabrication processes for packaged optical MEMS devices

New methodologies in computational nanoscience facilitated by the GRID computing environment

Optimizing inhalable nanoparticles

Aerosol drug delivery to the lung periphery using nanoscale technologies

Novel antimicrobial activity of nanocrystalline silver dressings

Development of miniature visual monitoring cameras at OIP

The smallsat TIR spectrometer MIBS (macro system enabled by micro system technology)

Towards the miniaturization of a space-borne electrostatic energy analyzer: the miniature enhanced geometry electrostatic analyzer (MEGEA)

Thermal design of an HTP microthruster

Integration of silicon circuit components onto plastic substrates using fluidic self-assembly

A high-voltage integrated circuit engine for a dielectrophoresis-based programmable micro-fluidic processor

Patterning nanometer resist features on planar & topography substrates using the 2-step NERIME FIB top surface imaging process

Genetically engineered polypeptide for differential recognition of platinum on microfabricated structures

Dynamic effects on peptide structure: molecular dynamics simulations of a peptide employing ensemble of peptides

Interfacial behavior of complex hydrocarbon fluids at elevated pressures and temperatures

Superparamagnetic particle embedded microprobe (SPEM) for GMR sensor sensitivity calibration

Microfabricated silicon nanopore membranes provide continuous delivery of biopharmaceuticals

Generation and recovery of sub-micron diameter fibrous aerosols

Model studies of magnetic particle retention in the conducting airways

Towards a mechanism for nanocrystalline silver efficacy in the wound environment: structure versus size

RF MEMS for space applications

Micro systems technology: the way to shrink sun sensors

The development of a cryogenic optical delay line for DARWIN

Next generation microbolometers for high resolution remote sensing

Finite temperature multiscale computational modeling of materials at nanoscale

Self-consistent combination of the three-dimensional RISM theory of molecular solvation with analytical gradients and the Amsterdam density functional package

Microscopic theory of liquid interfaces in molecular systems

Theoretical study of pressure and cosolvent effects on the solvation structure of staphylococcal nuclease

Electrokinetic flow in a wavy channel

Hydrogel microvalve device modeling and simulation

Using insolubility wave-front for polymer deposition on self-assembling microfabricated parts

Transient behaviour of streaming potential development in microfluidic channels

New world in soft-nano-materials

MEMS relays/switches

Modeling, simulation, and testing of the mechanical dynamics of an RF MEMS switch

Characteristics of fiber Bragg grating temperature sensor at elevated temperatures

Advanced MEMS for high power integrated distribution systems

Advanced microphotonic and MEMS technologies for the MEOS microsatellite Earth observation mission

The Dutch MST program MicroNed and its cluster MISAT

Nano-satellites, a fast way to pre-qualify new micro-technology

Microbolometer instrument payload design for a microsatellite mission

Performance of a 512/spl times/3 pixel microbolometer detector for space imaging applications

Optical MEMS pressure sensor using ring resonator on a circular diaphragm

Modal analysis of microgrippers used in assembly of MEMS devices

Reconfigurable ground plane membranes for analog/digital microstrip phase shifters and frequency agile antenna

Effect of gravity on the macroscopic advancing contact angle: an experimental investigation

Molecular dynamics simulation of the rupture of nanometer-sized oil/water interface

An Investigation of Femtosecond Laser Micromachining

Fabrication of the multi-PCR chamber with inner heat-sink materials using a micro-blaster etching technique

Differential reflection characteristics for optical probing of nanoscale anisotropic layered system

Study on the preparation and electro-deformation of EVOH-SO/sub 3/K IPMC

MEMS accelerometer with two thin film piezoelectric read-out

Analysis of electroosmotic flow with linear variable zeta potential

RF MEMS for low power wireless communications

Switching time, impact velocity and release response, of voltage and charge driven electrostatic switches

Characterization and analysis of vertically comb-driven micromirrors

Dynamic deflection of electrostatic MEMS

Cyclo-Olefin polymer direct bonding using low temperature plasma activation bonding

A method for crack detection in structures using piezoelectric sensors and actuators

The use of microelectromechanical systems for surge detection in gas turbine engines

Multiplexed fiber Bragg gratings for potential aerospace applications

High-speed dense channel fiber Bragg grating sensor array for structural health monitoring

Carbon nanotube-elastomer composites for use in dielectric polymer actuators

Modeling of the behavior of random carbon nanotubes during field emission

Flow-induced vibration and instability of carbon nanotubes

Modeling the zinc chelating rosette nanotube

A variational approach to microneedle design

Nonlinear dynamics in nanomechanical oscillators

Microneedle arrays for drug delivery and fluid extraction

III-V compound semiconductor nanotechnology for smart systems

A self-consistent theory of polymer solvation

Techniques for biocells sensing, detection and characterization

Microtubule stability studied by integral equation theory

Detection of encephalic and hemorrhagic viruses: integration of micro- and nano-fabrication with computational tools

Thermal stability of IrO/sub 2/ nanowires

Contact mechanics description of inelastic displacement response of a nano-positioning device

Nonlinear vibration of electrostatic MEMS under DC and AC applied voltage

Self assembly-promises and challenges

A new method of electrostatic force modeling for MEMS sensors and actuators

RF MEMs tunable inductor using bimorph microactuators

Design of a thermal-bubble-based micromachined accelerometer

A study on the effects of humidity, temperature, and pressure sensor on the piezoresistive film co-structure

Pulse-actuated micromechanical resonator using digital Kalman observer

Verifying finite element simulation for a piezoresistive MEMS sensor

Hysteresis spring single digital input bistable mechanism

Actuator materials for extreme environments

Versatile inertial displacement sensor for planar motion

The implementation of fuzzy-based path planning for car-like mobile robot

Expert system suitability in modeling and analysis of tool wear in drilling

2004 International Conference on MEMS, NANO and Smart Systems (ICMENS'04)

Proceedings International Conference on MEMS, NANO and Smart Systems

Microfabricated silicon nanopore membranes provide continuous delivery of biopharmaceuticals

Content Provider	IEEE Xplore Digital Library
Author	Gardner, P.
Copyright Year	2005
Description	Author affiliation: Stanford Univ., CA, USA (Gardner, P.)
Abstract	Continuous delivery of bio-pharmaceuticals can provide important patient benefits including improved safety, better compliance, and improved efficacy. Drugs released from devices implanted under the skin, including mechanical pumps, are able to reach a steady state level in plasma .In practice, however, mechanical pumps face two key limitations: small volume/drug carrying capacity and formulation instability. In general, for proper pumping action, the drug must be in solution within the device reservoir, either in an aqueous medium or in a biocompatible, water-miscible solvent such as ethanol or DMSO.The mechanism of delivery relies on the unexpected finding that diffusion from a reservoir containing a high concentration of a solute to a reservoir of lower concentration through microfabricated nanochannels.The small implantable device applicable to the delivery of a wide range of drugs, including biopharmaceuticals. Zero-order release of several molecules has been documented in vitro.The drug loaded into the NanoGATE reservoir need not be in solution with the diffusion release mechanism, it is possible to fill the reservoir with a suspension of the drug, significantly increasing the carrying capacity of the system. Moreover, this approach provides formulation options to improve the long term stability of the loaded drug not possible with existing mechanical systems.
File Size	62339
File Format	PDF
ISBN	0769523986
DOI	10.1109/ICMENS.2005.70
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-07-24
Publisher Place	Canada
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Silicon Nanoporous materials Biomembranes Drugs Reservoirs Safety Skin Steady-state Plasma devices Solvents
Content Type	Text
Resource Type	Article

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