NDLI: Monte Carlo simulation of diabetic macular edema changes on optical coherence tomography data

Content Provider	IEEE Xplore Digital Library
Author	Correia, A. Pinto, L. Araujo, A. Barbeiro, S. Caramelo, F. Menezes, P. Morgado, M. Serranho, P. Bernardes, R.
Copyright Year	2014
Description	Author affiliation: Dept. of Math., Univ. of Coimbra, Coimbra, Portugal (Pinto, L.; Araujo, A.; Barbeiro, S.) \|\| Dept. of Electr. & Comput. Eng., Univ. of Coimbra, Coimbra, Portugal (Menezes, P.) \|\| Assoc. for Innovation & Biomed. Res. on Light & Image, Coimbra, Portugal (Correia, A.; Bernardes, R.) \|\| Inst. for Biomed. Imaging & Life Sci., Univ. of Coimbra, Coimbra, Portugal (Caramelo, F.; Morgado, M.) \|\| Dept. of Sci. & Technol., Univ. Aberta, Lisbon, Portugal (Serranho, P.)
Abstract	Optical coherence tomography (OCT) scans were acquired from healthy controls and patients with diabetic macular edema (DME), a common complication of diabetes characterized by increased retinal thickness due to fluid accumulation. The collected OCT data was divided into three distinct groups: healthy subjects, DME patients with significantly increased outer nuclear layer (ONL) thickness and DME patients without visible changes in the ONL. For each group, the ONL was segmented and processed, yielding a representative A-scan. Using reference values for the physical and optical characteristics of the healthy human retina, we used a Monte Carlo method with a model for the ONL to simulate an A-scan for each group and compare it to the real OCT data. This allowed to identify which alterations in the cellular characteristics are responsible for the changes observed in the OCT scans of the diseased groups.
Sponsorship	IEEE Comput. Soc.
Starting Page	724
Ending Page	727
File Size	2262375
Page Count	4
File Format	PDF
ISBN	9781479921317
DOI	10.1109/BHI.2014.6864466
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-06-01
Publisher Place	Spain
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Retina Diabetes Monte Carlo methods Photonics Optical imaging Optical scattering
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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