NDLI: Fractal and image analysis of cytoskeletal changes in tumour cells due to the effects of maspin

Content Provider	IEEE Xplore Digital Library
Author	Al-Mamun, M.A. Ravenhill, L. Hossain, M.A. Farid, D.M. Bass, R.
Copyright Year	2014
Description	Author affiliation: Dept. of Appl. Sci., Univ. of Northumbria at Newcastle, Newcastle upon Tyne, UK (Bass, R.) \|\| Comput. Intell. Group, Univ. of Northumbria at Newcastle, Newcastle upon Tyne, UK (Al-Mamun, M.A.; Hossain, M.A.) \|\| Dept. of Comput. Sci. & Eng., United Int. Univ., Dhaka, Bangladesh (Farid, D.M.) \|\| Sch. of Biol. Sci., Univ. of East Anglia, Norwich, UK (Ravenhill, L.)
Abstract	Maspin (SERPINB5) is a type II metastasis suppressor that influences multiple cellular functions. To date, maspin has been shown to increase adhesion and apoptosis and to decrease cell migration, proliferation, invasion and metastases in tumour malignancy. At the subcellular level, maspin influences morphological changes in the cell cytoskeleton which regulates complex biological processes including cell migration, cell adhesion and EMT (epithelial to mesenchymal transition). Here non-Euclidian fractal and image analyses have been applied to measure changes in the actin cytoskeleton using confocal microscopy images to confirm the effects of maspin. Results show that maspin contributes to maintaining the regular epithelial like shape, increases cell-cell adhesion and restricts tumour cells from showing the pre-migration and EMT characteristics. Characterization of these changes in the actin cytoskeleton using microscopic image analysis will establish maspin as a potential prognostic marker in future.
Sponsorship	IEEE Comput. Soc.
Starting Page	209
Ending Page	212
File Size	516400
Page Count	4
File Format	PDF
ISBN	9781479921317
DOI	10.1109/BHI.2014.6864341
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-06-01
Publisher Place	Spain
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Fractals Adhesives Shape Tumors Microscopy Morphology Cancer
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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